Evidence map›Paper›PMID 33580817›Full record

ArticlePflugers Archiv : European journal of physiology2021

Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart.

Rebekka Medert, Andreas Jungmann, Staffan Hildebrand, Martin Busch, Dirk Grimm, Veit Flockerzi, Oliver J Müller, Patrick Most, Dagmar Schumacher, Marc Freichel

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Rebekka MedertInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-7571-3732
Andreas JungmannDZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany.
Staffan HildebrandInstitute of Pharmacology and Toxicology, University Clinic of Bonn, Bonn, Germany.
Martin BuschDZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany.
Dirk GrimmDepartment of Infectious Diseases/Virology, BioQuant, Medical faculty, Heidelberg University, Heidelberg, Germany.
Veit FlockerziInstitute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany.
Oliver J MüllerDepartment of Internal Medicine III, University of Kiel, Kiel, Germany.
Patrick MostDZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany.
Dagmar SchumacherInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Marc FreichelInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany. marc.freichel@pharma.uni-heidelberg.de.
Heidelberg University · DEChristian-Albrechts-Universität zu Kiel · DESaarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cation channel transient receptor potential melastatin 4 (TRPM4) is a calcium-activated non-selective cation channel and acts in cardiomyocytes as a negative modulator of the L-type Ca

Indexed as

Gene Transfer TechniquesTRPM Cation ChannelsAnimalsDependovirusGenetic VectorsMaleMiceMyocytes, CardiacRNA InterferenceRNA, Small InterferingTransduction, GeneticRNA, Small InterferingTRPM4 protein, mouseTRPM Cation ChannelsAdeno-associated virus serotype 9 (AAV9)Gene therapyRNAiTransient receptor potential (TRP) channelTRPM4

Identifiers

PMID33580817
PMCPMC7940300
OpenAlexW3127551413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.