ArticleEuropean journal of preventive cardiology2021
Associations between acute and long-term exposure to PM2.5 components and temperature with QT interval length in the VA Normative Aging Study.
Article in European journal of preventive cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Short-Term Impacts of PMGeoHealth · 2026Article
- PM2.5 Induces Cardiomyoblast Senescence via AhR-Mediated Oxidative Stress.Antioxidants (Basel, Switzerland) · 2024Article
- Personal Strategies to Reduce the Cardiovascular Impacts of Environmental Exposures.Circulation research · 2024Review
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Authors and funding
5 authors.
Funding
Abstract
aimsOur study adds to the sparse literature on the effect of multiple fine particulate matter (PM2.5) components on QT interval length, an outcome with high clinical relevance in vulnerable populations. To our knowledge, this is the first study to examine the association between spatiotemporally resolved exposures to PM2.5 components and QT interval length. METHODS AND
resultsAmong 578 men living in Eastern Massachusetts between 2000 and 2011, we utilized time-varying linear mixed-effects regressions with a random intercept to examine associations between acute (0-3 days), intermediate (4-28 days), and long-term (1 year) exposure to PM2.5 components, temperature, and heart-rate corrected QT interval (QTc). Each of the PM2.5 components and temperature was geocoded to the participant's residential address using validated ensemble and hybrid exposure models and gridMET predictions. We also evaluated whether diabetic status modified the association between PM2.5 components and QTc interval. We found consistent results that higher sulfate levels and colder temperatures were associated with significant longer QTc across all moving averages except the day of exposure. The greatest effect of sulfate and temperature was detected for the 28-day moving average. In the multi-pollutant model, each 1.5 µg/m3 IQR increase in daily sulfate was associated with a 15.1 ms [95% confidence interval (CI): 10.2-20.0] increase in QTc interval and in the single-pollutant models a 15.3 ms (95% CI: 11.6-19.1) increase in QTc interval. Other secondary particles, such as nitrate and organic carbon, also prolonged QT interval, while elemental carbon decreased QT interval. We found that diabetic status did not modify the association between PM2.5 components and QTc interval.
conclusionAcute and long-term exposure to PM2.5 components and temperature are associated with changes in ventricular repolarization as measured by QT interval.
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