Evidence map›Paper›PMID 33580733›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021

MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction.

Jeremy A Elman, Olivia K Puckett, Asad Beck, Christine Fennema-Notestine, Latonya K Cross, Anders M Dale, Graham M L Eglit, Lisa T Eyler, Nathan A Gillespie, Eric L Granholm and 20 more

Open access · hybridAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 80 citations in OpenAlex.

  1. Daily heart rate variability biofeedback training decreases locus coeruleus MRI contrast in younger adults in a randomized clinical trial.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023
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  9. Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  13. Observational
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  16. Early Changes in the Locus Coeruleus in Mild Cognitive Impairment with Lewy Bodies.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  17. Review
  18. Article
  19. Neuromelanin-sensitive MRI for mechanistic research and biomarker development in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 10 institutions in 1 country.

Jeremy A ElmanDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Olivia K PuckettDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Asad BeckGraduate Program in Neuroscience, University of Washington, Seattle, Washington, USA.
Christine Fennema-NotestineDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Latonya K CrossDepartment of Psychology, University of Hawaii Hilo, Hilo, Hawaii, USA.
Anders M DaleDepartment of Radiology, University of California San Diego, La Jolla, California, USA.
Graham M L EglitDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Lisa T EylerDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Nathan A GillespieVirginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Eric L GranholmDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Daniel E GustavsonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Donald J HaglerDepartment of Radiology, University of California San Diego, La Jolla, California, USA.
Sean N HattonCenter for Behavior Genetics of Aging, University of California San Diego, La Jolla, California, USA.
Richard HaugerDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Amy J JakDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Mark W LogueNational Center for PTSD: Behavioral Science Division, VA Boston Healthcare System, Boston, Massachusetts, USA.
Linda K McEvoyDepartment of Radiology, University of California San Diego, La Jolla, California, USA.
Ruth E McKenzieSchool of Education and Public Policy, Merrimack College, Andover, Massachusetts, USA.
Michael C NealeVirginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Matthew S PanizzonDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Chandra A ReynoldsDepartment of Psychology, University of California Riverside, Riverside, California, USA.
Mark Sanderson-CiminoCenter for Behavior Genetics of Aging, University of California San Diego, La Jolla, California, USA.
Rosemary ToomeyDepartment of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA.
Xin M TuFamily Medicine and Public Health, University of California San Diego, La Jolla, California, USA.
Nathan WhitselDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
McKenna E WilliamsCenter for Behavior Genetics of Aging, University of California San Diego, La Jolla, California, USA.
Hong XianDepartment of Epidemiology & Biostatistics, St. Louis University, St. Louis, Missouri, USA.
Michael J LyonsDepartment of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA.
Carol E FranzDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
William S KremenDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
University of California, San Diego · USVA San Diego Healthcare System · USBoston University · USVirginia Commonwealth University · USMerrimack College · USSaint Louis University · USUniversity of California, Riverside · USUniversity of Hawaii at Hilo · USUniversity of Washington · USVanderbilt University Medical Center · US

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
Effects of Androgen Deprivation Therapy on Preclinical Symptoms of Alzheimer's DiseaseR01AG056410 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PANIZZON, MATTHEW S · 2017 to 2021
$3.3M
Moderate alcohol use: risk or protective factor for age-related cognitive decline, mild cognitive impairment, and brain health in agingR01AG062483 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCEVOY, LINDA KATHLEEN · 2019 to 2021
$1.6M
Linking genetic subtypes of Alzheimer's disease to biological and cognitive heterogeneityK01AG063805 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A · 2021 to 2024
$516k
Practice Effects in Cognitive Aging: Implications for Biomarkers and Early DiagnosisF31AG064834 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDERSON-CIMINO, MARK · 2020 to 2021
$78k
NIA NIH HHS F31 AG064834NIA NIH HHS K01 AG063805NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG056410NIA NIH HHS R01 AG062483
6 · The paper itself

Abstract

introductionThe locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression.

methodsParticipants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin-sensitive magnetic resonance imaging (MRI) contrast-to-noise ratio (LC

resultsHeritability of LC DISCUSSION: Reduced LC integrity is associated with widespread differences across cognitive domains, daytime sleep-related dysfunction, and risk for aMCI. These findings in late-middle-aged adults highlight the potential of MRI-based measures of LC integrity in early identification of AD risk.

Indexed as

AgedAgingCognitionCognitive DysfunctionDisease ProgressionHumansLocus CoeruleusMagnetic Resonance ImagingMaleMemory DisordersNeuropsychological TestsSleepAlzheimer's diseaseheritabilitylocus coeruleusmild cognitive impairmentneuromelanin magnetic resonance imagingsleep-wake disturbance

Identifiers

PMID33580733
PMCPMC8248066
OpenAlexW3127198840

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.