Evidence map›Paper›PMID 33580472›Full record

Trial reportJournal of molecular neuroscience : MN2021

Altered IFN-γ Levels after Treatment of Epileptic Patients with Omega-3 Fatty Acids.

Soudeh Ghafouri-Fard, Mahnaz Hashemi, Mahboobeh Rafigh, Mohammad Amin Omrani, Bashdar Mahmud Hussen, Arezou Sayad, Mohammad Taheri

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Soudeh Ghafouri-FardDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahnaz HashemiMedical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Mahboobeh RafighMedical Genetics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Amin OmraniStudent Research Committee, Tehran University of Medical Sciences, Tehran, Iran.
Bashdar Mahmud HussenPharmacognosy Department, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
Arezou SayadUrogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ar.sayad@yahoo.com.
Mohammad TaheriUrology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. mohammad_823@yahoo.com.ORCID http://orcid.org/0000-0001-8381-0591
Shahid Beheshti University of Medical Sciences · IRGolestan University · IRHawler Medical University · IQMashhad University of Medical Sciences · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy is a frequent chronic disorder of the brain characterized by intermittent epileptic seizures caused by hypersynchronous discharge of neurons in the brain. Studies have reported the role of cytokines in the pathogenesis of epilepsy, and a number of investigations have shown decreased levels of omega-3 fatty acids in epileptic patients. We investigated differences in serum levels of two cytokines, transforming growth factor (TGF)-β and interferon (IFN)-γ, in 40 epileptic cases prior to and after treatment with omega-3 fatty acids. IFN-γ levels were significantly increased after the 16-week treatment period (P < 0.001). However, TGF-β levels remained unchanged (P = 0.14). Omega-3 fatty acid treatment may alter the immune response in epileptic patients. This should be considered in prescription of omega-3 fatty acid supplements in these patients. Future studies with larger sample sizes should verify the results of the current study.

Indexed as

AdultEpilepsyFatty Acids, Omega-3FemaleHumansInterferon-gammaMaleTransforming Growth Factor betaFatty Acids, Omega-3Interferon-gammaTransforming Growth Factor betaEpilepsyIFN-γOmega-3 fatty acidTGF-β

Identifiers

PMID33580472
OpenAlexW3128624160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.