Evidence map›Paper›PMID 33580459›Full record

ArticleMolecular biology reports2021

Increased level of long non coding RNA H19 is correlated with the downregulation of miR-326 and BCL-2 genes in pediatric acute lymphoblastic leukemia, a possible hallmark for leukemogenesis.

Mahtab Mofidi, Soheila Rahgozar, Shahrzad Pouyanrad

Abstract read
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In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Mahtab MofidiDepartment of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Postal Code 81746-73441, Hazer Jarib Street, Isfahan, Iran.
Soheila RahgozarDepartment of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Postal Code 81746-73441, Hazer Jarib Street, Isfahan, Iran. rahgozar@sci.ui.ac.ir.ORCID http://orcid.org/0000-0003-1376-255X
Shahrzad PouyanradDepartment of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Postal Code 81746-73441, Hazer Jarib Street, Isfahan, Iran.
University of Isfahan · IRIsfahan University of Technology · IR

Funding

Office of Vice Chancellor for Research and Technology, University of Isfahan 96/29729
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) and their role in competitive endogenous RNA (ceRNA) networks have emerged as fundamental debates in the biological processes of initiation and progression of cancer. This study aimed to identify and measure the expression levels of relevant ceRNA regulatory genes contributing to acute lymphoblastic leukemia (ALL). lncRNA H19 and BCL-2 mRNA were chosen based on in silico studies and their interactions with miR-326. Subsequently, the aforementioned coding/non-coding gene expression profiles were measured using qRT-PCR in 50 bone marrow samples, including 33 cases with pediatric ALL and 17 controls with no evidence of malignancy. lncRNA H19 was identified as an oncogenic factor which was noticeably increased in the newly diagnosed patients (P = 0.0019, AUC = 0.84) and negatively associated with miR-326 (r = -0.6, P = 0.02). Furthermore, a negative correlation was introduced between the transcriptional levels of miR-326 and the anti-apoptotic BCL-2 gene (r = -0.6, P = 0.028). The novel experimental and bioinformatic results achieved in this study may provide new insights into the molecular leukemogenesis of pediatric ALL.

Indexed as

B-LymphocytesCarcinogenesisChildChild, PreschoolFemaleGene Expression Regulation, NeoplasticHumansInfantInfant, NewbornMaleMicroRNAsPediatricsPrecursor Cell Lymphoblastic Leukemia-LymphomaProto-Oncogene Proteins c-bcl-2RNA, Long NoncodingRNA, MessengerBCL2 protein, humanH19 long non-coding RNAMicroRNAsMIRN326 microRNA, humanProto-Oncogene Proteins c-bcl-2RNA, Long NoncodingRNA, MessengerBCL-2BiomarkerLeukemogenesislncRNA H19miR326Pediatric acute lymphoblastic leukemia

Identifiers

PMID33580459
OpenAlexW3128333807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.