ArticleCommunications biology2021
Midgut development in rat embryos using microcomputed tomography.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Cantrell Syndrome and the One Health Perspective: A Unified Review of Human and Comparative Cases.Veterinary sciences · 2026Review
- Superior Mesenteric Artery during Intestinal Loop Formation and Its Positional Changes from the Extracoelom to the Abdominal Cavity.Cells, tissues, organs · 2026Article
- Midgut protrusion, rotation, and retraction induced by temporal alteration in differential growth.Biomechanics and modeling in mechanobiology · 2025Article
- Ectopic intestinal cyst in the liver of a Sprague-Dawley rat.Journal of toxicologic pathology · 2025Article
- Microcomputed Tomography in the Adriamycin Rat Model of Malformations-Preliminary Results.Biomolecules · 2025Article
- Development of the foregut and the formation of the trachea and esophagus in rat embryos. A symphony of confusion.Frontiers in cell and developmental biology · 2023Article
- Bovine omphalocele: errors in embryonic development, veterinarian importance, and the way forward.Veterinary research communications · 2022Review
- Topographical relationships of the yolk sac remnant and vitelline vessels with the midgut loop in the extra-embryonic coelom of human embryos.Anatomy & cell biology · 2022Article
- The return process of physiological umbilical herniation in human fetuses: The possible role of the vascular tree and umbilical ring.Journal of anatomy · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of the mammalian gut was first described more than a century ago. Since then, it has been believed that a series of highly orchestrated developmental processes occur before the intestine achieves its final formation. The key steps include the formation of the umbilicus, the so-called "physiological herniation" of the midgut into the umbilical cord, an intestinal "rotation", and the "return of the gut" into the abdominal cavity. However, this sequence of events is predominantly based on histological sections of dissected embryos, a 2D technique with methodological limitations. For a better understanding of spatial relationships in the embryo, we utilized microcomputed tomography (µCT), a nondestructive 3D imaging method. Here, we show the detailed processes and mechanisms of intestinal development in rat embryos, including the development of the umbilicus, the formation of loops inside the umbilical coelom, and the subsequent shift of these loops into the abdominal cavity. Our 3D datasets of developing intestines will substantially advance the understanding of normal mammalian midgut embryology and offer new possibilities to reveal unknown mechanisms in the pathogenesis of congenital disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.