ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021
The anterior retrosplenial cortex encodes event-related information and the posterior retrosplenial cortex encodes context-related information during memory formation.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 49 citations in OpenAlex.
- Circuit-informed modulation of traumatic memory in PTSD: integrating extinction, suppression, and reconsolidation.Molecular psychiatry · 2026Review
- Unconditional stimulus deflation is stimulus specific.Learning & behavior · 2026Article
- Differential modulation of aversive signaling by expectation across the cingulate cortex.bioRxiv : the preprint server for biology · 2026Article
- Reductions in protein degradation in the retrosplenial cortex regulate contextual fear memory formation in a sex-independent manner.Neurobiology of learning and memory · 2026Article
- Adolescent alcohol exposure disrupts extinction learning and retrosplenial cortex physiology in adult males.bioRxiv : the preprint server for biology · 2025Article
- Combinative Protein Expression of Immediate Early Genes c-Fos, Arc, and Npas4 Along Aversive and Appetitive Experience-Related Neural Networks.Hippocampus · 2025Article
- Long-Term Memory Engrams From Development to Adulthood.Hippocampus · 2025Review
- Astrocytic P2X7 receptor in retrosplenial cortex drives electroacupuncture analgesia.Purinergic signalling · 2025Article
- Single neurons and networks in the mouse claustrum integrate input from widespread cortical sources.eLife · 2025Article
- The interval between conditional stimulus onset and unconditional stimulus onset, not training-to-test interval, determines patterns of immediate early gene expression in the anterior retrosplenial cortex.Neurobiology of learning and memory · 2025Article
- The retrosplenial cortical role in delayed spatial alternation.Neurobiology of learning and memory · 2024Article
- Behavioral outputs and overlapping circuits between conditional fear and active avoidance.Neurobiology of learning and memory · 2024Review
- The Retrosplenial Cortical Role in Delayed Spatial Alternation.bioRxiv : the preprint server for biology · 2024Article
- Fear extinction is impaired in aged rats.GeroScience · 2024Article
- From vision to memory: How scene-sensitive regions support episodic memory formation during child development.Developmental cognitive neuroscience · 2024Article
- Generalization and discrimination of inhibitory avoidance differentially engage anterior and posterior retrosplenial subregions.Frontiers in behavioral neuroscience · 2024Article
- Retrosplenial cortex and aversive conditioning.Frontiers in behavioral neuroscience · 2024Review
- Fear Reduced Through Unconditional Stimulus Deflation Is Behaviorally Distinct From Extinction and Differentially Engages the Amygdala.Biological psychiatry global open science · 2023Article
- Article
- The clock gene Per1 is necessary in the retrosplenial cortex-but not in the suprachiasmatic nucleus-for incidental learning in young and aging male mice.Neurobiology of aging · 2023Article
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4 authors at 1 institution in 1 country.
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Abstract
The retrosplenial cortex (RSC) is extensively interconnected with the dorsal hippocampus and has several important roles in learning and memory. Recent work has demonstrated that certain types of context-dependent learning are selectively impaired when the posterior, but not the anterior, region of the RSC is damaged, suggesting that the role of the RSC in memory formation may not be uniform along its rostro-caudal axis. The current experiments tested the idea that the anterior and posterior portions of the rat RSC contribute to different aspects of memory formation. We first confirmed that brief optogenetic inhibition of either the anterior or posterior RSC resulted in decreased local cellular activity as indexed by immediate early gene zif268 expression and that this decrease was restricted to the target region within RSC. We then found that silencing the anterior or posterior RSC during trace fear training trials had different effects on memory: While inhibiting neural activity in the anterior RSC had a selective impact on behavior evoked by the auditory CS, inhibition of the posterior RSC selectively impaired memory for the context in which training was conducted. These results contribute to a growing literature that supports functionally distinct roles in learning and memory for subregions of the RSC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.