Evidence map›Paper›PMID 33580091›Full record

ArticleScientific reports2021

Cholesterol as a modulator of cannabinoid receptor CB

Alexei Yeliseev, Malliga R Iyer, Thomas T Joseph, Nathan J Coffey, Resat Cinar, Lioudmila Zoubak, George Kunos, Klaus Gawrisch

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Genetically Encoded CBInternational journal of molecular sciences · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Lipid regulation of the glucagon receptor family.The Journal of endocrinology · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Special issue for Klaus Gawrisch.Biophysical journal · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Alexei YeliseevNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20852, USA. yeliseeva@mail.nih.gov.
Malliga R IyerNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20852, USA. malliga.iyer@nih.gov.
Thomas T JosephDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Nathan J CoffeyNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20852, USA.
Resat CinarNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20852, USA.
Lioudmila ZoubakNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20852, USA.
George KunosNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20852, USA.
Klaus GawrischNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20852, USA.
National Institutes of Health · USNational Institute on Alcohol Abuse and Alcoholism · USUniversity of Pennsylvania · US

Funding

Endocannabinoids And Energy HomeostasisZIAAA000350 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI KUNOS, GEORGE · 2009 to 2025
$28.4M
Fibroproliferative mechanisms in organ fibrosisZIAAA000355 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI CINAR, RESAT · 2021 to 2025
$6.6M
Novel Cannabinoid Receptor ModulatorsZIAAA000360 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI IYER, MALLIGA · 2021 to 2025
$5.9M
6 · The paper itself

Abstract

Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB

Indexed as

CholesterolEscherichia coliHEK293 CellsHumansMolecular Dynamics SimulationReceptor, Cannabinoid, CB2CholesterolReceptor, Cannabinoid, CB2

Identifiers

PMID33580091
PMCPMC7881127
OpenAlexW3127249920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.