Evidence map›Paper›PMID 33580090›Full record

ArticleScientific reports2021

Glypican-3 targeted delivery of

Kevin P Labadie, Andrew D Ludwig, Adrienne L Lehnert, Donald K Hamlin, Aimee L Kenoyer, Kevin M Sullivan, Sara K Daniel, Tara N Mihailovic, Jonathan G Sham, Johnnie J Orozco and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Diagnosis and Treatment Response Monitoring of Liver Cancer Using Glypican-3-Targeted Single-Domain Antibody PET.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  6. Journal of pharmaceutical analysis · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. PET imaging of hepatocellular carcinoma by targeting tumor-associated endothelium using [European journal of nuclear medicine and molecular imaging · 2022
    Article
  13. Glypican-3-TargetedJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  14. Imaging ligands targeting glypican-3 receptor expression in hepatocellular carcinoma.American journal of nuclear medicine and molecular imaging · 2022
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Kevin P LabadieDepartment of Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Box 356410, Health Sciences Bldg. Room BB-442, Seattle, WA, 98195-6410, USA.
Andrew D LudwigDepartment of Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Box 356410, Health Sciences Bldg. Room BB-442, Seattle, WA, 98195-6410, USA.
Adrienne L LehnertDepartment of Radiology, University of Washington, Seattle, WA, USA.
Donald K HamlinDepartment of Radiology, University of Washington, Seattle, WA, USA.
Aimee L KenoyerClinical Research Division, Fred Hutch Cancer Research Center, Seattle, WA, USA.
Kevin M SullivanDepartment of Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Box 356410, Health Sciences Bldg. Room BB-442, Seattle, WA, 98195-6410, USA.
Sara K DanielDepartment of Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Box 356410, Health Sciences Bldg. Room BB-442, Seattle, WA, 98195-6410, USA.
Tara N MihailovicDepartment of Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Box 356410, Health Sciences Bldg. Room BB-442, Seattle, WA, 98195-6410, USA.
Jonathan G ShamDepartment of Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Box 356410, Health Sciences Bldg. Room BB-442, Seattle, WA, 98195-6410, USA.
Johnnie J OrozcoClinical Research Division, Fred Hutch Cancer Research Center, Seattle, WA, USA.
Raymond S YeungDepartment of Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Box 356410, Health Sciences Bldg. Room BB-442, Seattle, WA, 98195-6410, USA.
Delphine L ChenDepartment of Radiology, University of Washington, Seattle, WA, USA.
D Scott WilburDepartment of Radiology, University of Washington, Seattle, WA, USA.
Robert S MiyaokaDepartment of Radiology, University of Washington, Seattle, WA, USA.
James O ParkDepartment of Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Box 356410, Health Sciences Bldg. Room BB-442, Seattle, WA, 98195-6410, USA. jopark@uw.edu.
University of Washington Medical Center · USUniversity of Washington · USCancer Research Center · USFred Hutch Cancer Center · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Small Animal CT SystemS10OD017980 · OD · UNIVERSITY OF WASHINGTON · PI MIYAOKA, ROBERT S · 2014 to 2014
$547k
Small Animal PET SystemS10RR024689 · NCRR · UNIVERSITY OF WASHINGTON · PI MIYAOKA, ROBERT S · 2008 to 2008
$500k
Caliper Life Sciences IVIS Lumina II imaging systemS10OD010652 · OD · UNIVERSITY OF WASHINGTON · PI COOKSON, BRAD T · 2012 to 2012
$161k
NCI NIH HHS P30 CA015704NCRR NIH HHS S10 RR024689NIH HHS S10 OD010652NIH HHS S10 OD017980
6 · The paper itself

Abstract

Glypican-3 (GPC3) is a tumor associated antigen expressed by hepatocellular carcinoma (HCC) cells. This preclinical study evaluated the efficacy of a theranostic platform using a GPC3-targeting antibody αGPC3 conjugated to zirconium-89 (

Indexed as

AnimalsCarcinoma, HepatocellularCell Line, TumorDrug Delivery SystemsGlypicansHumansLiver NeoplasmsMiceMice, NudePositron-Emission TomographyPrecision MedicineRadioimmunotherapyRadioisotopesRadiopharmaceuticalsTissue DistributionXenograft Model Antitumor AssaysGlypicansRadioisotopesRadiopharmaceuticalsYttrium-90Yttrium RadioisotopesZirconiumZirconium-89

Identifiers

PMID33580090
PMCPMC7881163
OpenAlexW3129034123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.