ArticleNature communications2021
EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
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67 citing papers in PubMed, 152 citations in OpenAlex.
- Rewiring NADH Metabolism Through NQO1-Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Flavonoids as Modulators of the p53-Bcl-2 Axis in Cancer: Molecular Mechanisms and Therapeutic Implications.Pharmaceutics · 2026Review
- Targeting the intrinsically disordered AR-NTD through a machine learning-based enhanced sampling workflow.Nature communications · 2026Article
- The role of e3 ubiquitin ligases and deubiquitinating enzymes in hepatocellular carcinoma.Cell biology and toxicology · 2026Review
- Nitrogen-Boosted HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- DIRseq: a method for predicting drug-interacting residues of intrinsically disordered proteins from sequences.bioRxiv : the preprint server for biology · 2025Article
- Ensemble Docking for Intrinsically Disordered Proteins.Journal of chemical information and modeling · 2025Article
- Covalent Adducts Formed by the Androgen Receptor Transactivation Domain and Small Molecule Drugs Remain Disordered.Journal of chemical information and modeling · 2025Article
- Atomistic molecular dynamics simulations of intrinsically disordered proteins.Current opinion in structural biology · 2025Review
- Conformational modulation of intrinsically disordered transactivation domains for cancer therapy.PNAS nexus · 2025Review
- Human papilloma virus (HPV) mediated cancers: an insightful update.Journal of translational medicine · 2025Review
- A Pharmacokinetic-Pharmacodynamic Study of Protosappanoside D, a Component Derived fromInternational journal of molecular sciences · 2025Article
- Two shikimate dehydrogenases play an essential role in the biosynthesis of galloylated catechins in tea plants.Horticulture research · 2025Article
- Ensemble docking for intrinsically disordered proteins.bioRxiv : the preprint server for biology · 2025Article
- Simultaneous binding of quercetin and catechin to FOXO3 enhances IKKα transcription inhibition and suppression of oxidative stress-induced acute alcoholic liver injury in rats.Journal of advanced research · 2025Article
- The Association between Tea Consumption and Bladder Cancer Risk Based on the Bladder Cancer Epidemiology and Nutritional Determinants (BLEND) International Consortium.Nutrition and cancer · 2025Article
- Natural epigallocatechin-3-gallocarboxylate nanoformulation loaded doxorubicin to construct a novel and low cardiotoxicity chemotherapeutic drug for high-efficiency breast cancer therapy.Journal of nanobiotechnology · 2024Article
- Stephanine Protects Against Osteoporosis by Suppressing Osteoclastogenesis via Inhibition of the RANKL-RANK Interaction.Journal of cellular and molecular medicine · 2024Article
- Epigallocatechin-3-gallate at the nanoscale: a new strategy for cancer treatment.Pharmaceutical biology · 2024Review
7 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 7 institutions in 2 countries.
Jing Zhao *College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Alan Blayney *Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.ORCID 0000-0003-0741-1550
Xiaorong LiuDepartment of Chemistry, University of Massachusetts, Amherst, MA, USA.
Lauren GandyCenter for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Weihua JinCenter for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Lufeng YanCenter for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Jeung-Hoi HaDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
Ashley J CanningDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
Michael ConnellyDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.ORCID 0000-0003-3684-6385
Chao YangDepartment of Chemistry, New York University, New York, NY, USA.
Xinyue LiuCenter for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Yuanyuan XiaoCenter for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Michael S CosgroveDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
Sozanne R SolmazDepartment of Chemistry, State University of New York at Binghamton, Binghamton, NY, USA.
Yingkai ZhangDepartment of Chemistry, New York University, New York, NY, USA.ORCID 0000-0002-4984-3354
David BanMerck Research Laboratories, Mass Spectrometry and Biophysics, Kenilworth, NJ, USA.
Jianhan ChenDepartment of Chemistry, University of Massachusetts, Amherst, MA, USA.ORCID 0000-0002-5281-1150
Stewart N LohDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
Chunyu WangCenter for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA. wangc5@rpi.edu.ORCID 0000-0001-5165-7959
Rensselaer Polytechnic Institute · USSUNY Upstate Medical University · USBinghamton University · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USNew York University · USNew York University Shanghai · CNUniversity of Massachusetts Amherst · US
Funding
Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3MComputational modulator design and machine learning to target protein-protein interactionsR35GM127040 · NIGMS · NEW YORK UNIVERSITY · PI Yingkai Zhang · 2018 to 2026
$4.6MMolecular Mechanisms for the Assembly and Regulation of the MLL1 Core ComplexR01CA140522 · NCI · UPSTATE MEDICAL UNIVERSITY · PI COSGROVE, MICHAEL S. · 2010 to 2019
$3.6MStructural Mechanisms of Hedgehog Autoprocessing in Physiology and DiseaseR01CA206592 · NCI · RENSSELAER POLYTECHNIC INSTITUTE · PI CALLAHAN, BRIAN PATRICK, WANG, CHUNYU · 2017 to 2021
$2.0MThe Alzheimer's Disease Clinical and Translational Research (ADCTR) Training ProgramT32AG057464 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI WANG, CHUNYU · 2017 to 2021
$1.6MMulti-scale enhanced sampling of disordered proteins: Admin Supplement InstrumentationR01GM114300 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI CHEN, JIANHAN · 2016 to 2020
$1.5MCell cycle-specific recognition of the cell nucleus as cargo for dynein-dependent transportR15GM128119 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI SOLMAZ, SOZANNE R · 2018 to 2018
$449kNCI NIH HHS R01 CA140522NCI NIH HHS R01 CA206592NIA NIH HHS T32 AG057464NIGMS NIH HHS P30 GM124166NIGMS NIH HHS R01 GM114300NIGMS NIH HHS R15 GM128119NIGMS NIH HHS R35 GM127040
Abstract
Epigallocatechin gallate (EGCG) from green tea can induce apoptosis in cancerous cells, but the underlying molecular mechanisms remain poorly understood. Using SPR and NMR, here we report a direct, μM interaction between EGCG and the tumor suppressor p53 (K
Indexed as
ApoptosisBinding SitesCatechinCell Line, TumorEpitopesHumansProtein BindingProto-Oncogene Proteins c-mdm2Scattering, Small AngleTeaTumor Suppressor Protein p53UbiquitinationUbiquitin-Protein LigasesX-Ray DiffractionCatechinepigallocatechin gallateEpitopesMDM2 protein, humanProto-Oncogene Proteins c-mdm2TeaTP53 protein, humanTumor Suppressor Protein p53Ubiquitin-Protein Ligases
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