ArticleJournal of Alzheimer's disease : JAD2021
The Utility of Assessing Health-Related Quality of Life to Predict Cognitive Decline and Dementia.
Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- A Hearing Intervention and Health-Related Quality of Life in Older Adults: A Secondary Analysis of the ACHIEVE Randomized Clinical Trial.JAMA network open · 2024Trial
- Associations Between Blood Concentrations of Sex Hormones and Physical Function in Community-Dwelling Older Women: A Prospective Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Trial
- Baseline health-related quality of life predicts falls: a secondary analysis of a randomized controlled trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Trial
- Psychiatric morbidity is associated with cognitive impairment, whereas diagnostic category may shape its profile: a transdiagnostic study of inflammation, salivary biomarkers, and health-related quality of life.Frontiers in psychology · 2026Article
- Longitudinal trajectories of health-related quality of life and their predictors among community-dwelling older adults.Scientific reports · 2025Article
- Wellbeing and memory function: testing bidirectional associations in the English Longitudinal Study of Ageing (ELSA).Aging & mental health · 2025Article
- Lower mental health related quality of life precedes dementia diagnosis: findings from the EPIC-Norfolk prospective population-based study.European journal of epidemiology · 2024Article
- Association between healthy lifestyle factors and health-related quality of life among Chinese adolescents: the moderating role of gender.Health and quality of life outcomes · 2023Article
- Cognitive impairment and health-related quality of life amongst older Australians: evidence from a longitudinal investigation.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- The Longitudinal Association Between Frailty, Cognition, and Quality of Life in Older Europeans.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Association between cardiopulmonary function, health-related quality of life and cognitive impairment among the older nursing home residents in Shanghai, China.Primary health care research & development · 2023Article
- Maternal adverse childhood experiences and health-related quality of life in preschool children: a cross-sectional study.Child and adolescent psychiatry and mental health · 2023Article
- Physical and mental health quality of life among underserved African American and Latino older adults.Ethnicity & health · 2023Article
- Quality of life profiles and their associations with depressive symptoms and cognitive impairment of community-dwelling older adults in Hong Kong.Frontiers in public health · 2023Article
- Adult Child Schooling and Older Parents' Cognitive Outcomes in the Survey of Health, Aging and Retirement in Europe (SHARE): A Quasi-Experimental Study.American journal of epidemiology · 2022Article
- Trajectories of physical health-related quality of life and the risk of incident cardiovascular disease events and all-cause mortality in older people.American heart journal plus : cardiology research and practice · 2022Article
- The role of health-related quality of life in risk prediction for developing cardiovascular disease, dementia and all-cause death among general older adults.Frontiers in public health · 2022Article
- Health-related heterogeneity in brain aging and associations with longitudinal change in cognitive function.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 5 countries.
Funding
Abstract
backgroundHealth-related quality of life (HRQoL) has been shown to predict adverse health outcome in the general population.
objectiveWe examined the cross-sectional association between HRQoL and cognitive performance at baseline. Next, we explored whether baseline HRQoL predicted 5-year incident cognitive decline and dementia and whether there were gender differences.
methods19,106 community-dwelling participants from the ASPirin in Reducing Events in the Elderly (ASPREE) trial, aged 65-98 years, free of major cognitive impairments, and completed the HRQoL 12-item short-form (SF-12) at baseline (2010-2014), were followed until June 2017. The physical (PCS) and mental component scores (MCS) of SF-12 were calculated. The cognitive tests were assessed at baseline, year 1, 3, 5, and 7 or close-out visit. Cognitive decline was defined as > 1.5 SD drop from baseline on any of the cognitive tests. Dementia was adjudicated according to DSM-IV criteria. Linear and Cox proportional-hazards regressions were used to examine the cross-sectional and longitudinal associations respectively.
resultsAt baseline, higher PCS and MCS were associated with better cognition. Over a median 4.7-year follow-up, higher MCS was associated with a reduced risk of cognitive decline and dementia (12% and 15% respectively, per 10-unit increase) and a 10-unit higher PCS was associated with a 6% decreased risk of cognitive decline. PCS did not predict dementia incidence. Findings were not different by gender.
conclusionOur study found that higher HRQoL, in particular MCS, predicted a reduced risk of cognitive decline and dementia over time in community-dwelling older people.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.