Evidence map›Paper›PMID 33579598›Full record

SynthesisBrazilian journal of otorhinolaryngology

Osteomyelitis of the jaws in patients with pycnodysostosis: a systematic review.

Glória Maria de França, Fernanda Aragão Felix, Everton Freitas de Morais, Maurília Raquel de Souto Medeiros, Ana Cláudia de Macedo Andrade, Hébel Cavalcanti Galvão

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Glória Maria de FrançaUniversidade Federal do Rio Grande do Norte (UFRN), Departamento de Odontologia, Programa de Pós-Graduação em Ciências Odontológicas, Área de Concentração em Patologia Oral e Estomatologia, Natal, RN, Brazil. Electronic address: gloriafracam@gmail.com.
Fernanda Aragão FelixUniversidade Federal do Rio Grande do Norte (UFRN), Centro de Biociências, Programa de Pós-Graduação em Ciências Odontológicas, Área de Concentração em Biologia Oral, Natal, RN, Brazil.
Everton Freitas de MoraisUniversidade Federal do Rio Grande do Norte (UFRN), Departamento de Odontologia, Programa de Pós-Graduação em Ciências Odontológicas, Área de Concentração em Patologia Oral e Estomatologia, Natal, RN, Brazil.
Maurília Raquel de Souto MedeirosUniversidade Federal do Rio Grande do Norte (UFRN), Departamento de Odontologia, Programa de Pós-Graduação em Ciências Odontológicas, Área de Concentração em Patologia Oral e Estomatologia, Natal, RN, Brazil.
Ana Cláudia de Macedo AndradeUniversidade Federal do Rio Grande do Norte (UFRN), Departamento de Odontologia, Programa de Pós-Graduação em Ciências Odontológicas, Área de Concentração em Patologia Oral e Estomatologia, Natal, RN, Brazil.
Hébel Cavalcanti GalvãoUniversidade Federal do Rio Grande do Norte (UFRN), Departamento de Odontologia, Programa de Pós-Graduação em Ciências Odontológicas, Área de Concentração em Patologia Oral e Estomatologia, Natal, RN, Brazil.
Universidade Federal do Rio Grande do Norte · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPycnodysostosis is a rare autosomal recessive syndrome that provides the abnormal bone metabolism that increases the susceptibility of patients to develop osteomyelitis.

objectiveThis systematic review was conducted to analyze the risk factors associated with the development of complications in the jaws (fractures and osteomyelitis), as well as their clinical-pathological characteristics and therapeutic approaches in patients with pycnodysostosis.

methodsSearches were performed in the PubMed, Web of Science, Scopus, Lilacs, and Cochrane databases. Case reports or case series that met the eligibility criteria according to the PRISMA statement were included. The full texts of 31 articles were retrieved. Twenty of these articles published between 1969 and 2018 were selected, which described 26 cases of osteomyelitis in patients with pycnodysostosis.

resultsThe mean age of the patients was 37.84 years; the male-to-female was 1.36:1. The mandible was the most affected site (76.9%). Tooth extraction was the main risk factor for osteomyelitis (61.5%), followed by infection (26.8%) and mandibular fracture (23.0%). Antibiotic therapy alone or combined with some surgical procedure was the treatment used in most cases (80.7%).

conclusionThe findings of this review showed that patients with pycnodysostosis are more likely to develop osteomyelitis of the jaws after surgical procedures, especially tooth extraction which remains the main risk factor for its establishment. In addition, prophylactic antibiotic-therapy in the pre- and postoperative periods may prevent the development of osteomyelitis in pycnodysostosis.

Indexed as

OsteomyelitisPycnodysostosisAdultFemaleHumansMaleMandibleCathepsin KDiagnosisJawsOsteomyelitisPycnodysostosis

Identifiers

PMID33579598
PMCPMC9422419
OpenAlexW3127455712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.