Evidence map›Paper›PMID 33579526›Full record

ArticleThe Journal of allergy and clinical immunology2021

Prevalence and characteristics of peanut allergy in US adults.

Christopher Warren, Dawn Lei, Scott Sicherer, Robert Schleimer, Ruchi Gupta

Open access · greenAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 66 citations in OpenAlex.

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  8. Sexual Dimorphism in Allergic and Mast Cell-Associated Diseases.Clinical reviews in allergy & immunology · 2026
    Review
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  17. Structural determinants of peanut-induced anaphylaxis.The Journal of allergy and clinical immunology · 2025
    Article
  18. Review
  19. Article
  20. What's New About the Newest Vital Sign?Health literacy research and practice · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Christopher WarrenCenter for Food Allergy and Asthma Research, Northwestern University Feinberg School of Medicine, Chicago, Ill; Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, Calif.
Dawn LeiDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
Scott SichererElliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY.
Robert SchleimerDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Ruchi GuptaCenter for Food Allergy and Asthma Research, Northwestern University Feinberg School of Medicine, Chicago, Ill; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill. Electronic address: r-gupta@northwestern.edu.
Northwestern University · USIcahn School of Medicine at Mount Sinai · US

Funding

FORWARD Supplement Standardizing EHR Data CollectionR01AI130348 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ruchi S Gupta · 2017 to 2026
$10.9M
Intervention to Reduce Early (Peanut) Allergy in Children (iREACH)U01AI138907 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI GUPTA, RUCHI S · 2019 to 2023
$8.0M
US Prevalence, Distribution and Determinants of Adult and Childhood Food AllergyR21AI135702 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI GUPTA, RUCHI S · 2018 to 2019
$433k
NIAID NIH HHS R01 AI130348NIAID NIH HHS R21 AI135702NIAID NIH HHS U01 AI138907
6 · The paper itself

Abstract

backgroundPeanut allergy (PA) is the leading pediatric food allergy and a common cause of anaphylaxis. Little is known, however, on the prevalence and characteristics of PA in the adult population and whether phenotypic differences exist between adult-onset and childhood-onset PA.

objectivesThis study describes the current US population-level burden of adult PA.

methodsA cross-sectional food allergy survey was administered via phone and web in 2015 and 2016, resulting in nationally representative complex-survey weighted data for 40,443 adults. Reported food allergies were considered "convincing" if symptoms to specific allergens were consistent with an IgE-mediated reaction.

resultsThe prevalence of current self-reported PA was 2.9% among US adults, with 1.8% having convincing PA. Over 17% of adults with peanut allergy reported onset of their PA in adulthood. In adults with childhood-onset PA, 75.4% reported physician-diagnosed PA, compared with only 58.9% of adult-onset PA. Despite a similar frequency of food allergy-related emergency department visits within the past year (approximately 1 in 5 adults with PA allergy), adults with childhood-onset PA were significantly more likely to have a current epinephrine prescription compared with those with adult-onset PA (56% vs 44% respectively; P = .02) and were more likely to use an epinephrine autoinjector (48% vs 35%, P = .01).

conclusionsApproximately 4.6 million US adults have PA-over 800,000 of whom appear to have developed their PA after age 18 years. Further examination of phenotypic differences between childhood-onset and adult-onset PA may improve understanding and management of adult PA.

Indexed as

AllergensCross-Sectional StudiesHumansPeanut HypersensitivityPrevalencePublic Health SurveillanceSymptom AssessmentUnited StatesAllergensadult-onset food allergyatopyFood allergypeanut allergyprevalence

Identifiers

PMID33579526
PMCPMC12341317
OpenAlexW3127870570

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.