Evidence map›Paper›PMID 33579397›Full record

ArticleComparative medicine2021

Effects of Chronic Viral Infection on Lymphocyte Populations in Middle-aged Baboons (

Erin L Willis, Richard Eberle, Roman F Wolf, Gary L White, Dianne McFarlane

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comparative medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Roles of cytokines in modulatingFrontiers in parasitology · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Erin L WillisDepartment of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma.
Richard EberleDepartment of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma.
Roman F WolfDepartment of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Current Address: Oklahoma City Veterans Administration Health Care System, Oklahoma City, Oklahoma.
Gary L WhiteDepartment of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Current Address: Primate Consulting, Edmond, Oklahoma.
Dianne McFarlaneDepartment of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma;, Email: diannem@okstate.edu.
Oklahoma State University · USUniversity of Oklahoma Health Sciences Center · US

Funding

ZFC3H1 Regulation of Host Defense and Influenza A Virus PathogenesisP20GM103648 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI PATRAUCHAN, MARIANNA M. A. · 2013 to 2022
$22.3M
Baboon Research Resource ProgramP40OD010988 · OD · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI BANKS, RON E · 2012 to 2018
$9.0M
OUHSC Specific Pathogen Free Baboon Research ResourceP40OD010431 · OD · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI BANKS, RON E, PAPIN, JAMES F · 2013 to 2017
$3.8M
NIGMS NIH HHS P20 GM103648NIH HHS P40 OD010431NIH HHS P40 OD010988
6 · The paper itself

Abstract

Aging of the immune system is characterized by the loss of naïve T-cells, increased inflammation, and immune function impairment. Chronic infection with cytomegalovirus is thought to play a role in age-related changes in immunity. Therefore, to assess the effect of pathogens such as cytomegalovirus on the immune system, we determined lymphocyte populations and inflammatory markers over a 3-y period in captive, middle-age baboons, with various exposure to pathogens and shedding pressure. Groups included SPF (i.e., pathogen-negative;

Indexed as

Cytomegalovirus InfectionsPapio anubisAgingAnimalsPapioT-Lymphocytes

Identifiers

PMID33579397
PMCPMC8063200
OpenAlexW3128844295

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.