ArticleBMC ophthalmology2021
Quantitative assessment of vascular density in diabetic retinopathy subtypes with optical coherence tomography angiography.
Article in BMC ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Outcome of pars plana vitrectomy with and without internal limiting membrane peeling in proliferative diabetic retinopathy.International ophthalmology · 2026Trial
- Diabetes May Modulate the Association Between Age and Optical Coherence Tomography Angiography Parameters: A Serial, Cross-Sectional Study.Journal of personalized medicine · 2026Article
- Associations Between Retinal Microvasculature, Orbital Blood Flow, and Cerebral Blood Flow in Healthy Adults.Investigative ophthalmology & visual science · 2025Article
- OCTA-ReVABiomedical optics express · 2025Article
- Predictive Vascular Changes in OCTA in Diabetic Patients.Biomedicines · 2025Article
- Quantitative Analysis of Early Retinal Changes and OCT Parameters in Diabetic Subjects with and Without Retinopathy.Diagnostics (Basel, Switzerland) · 2025Article
- Detection of Retinal and Choriocapillaris Microvascular Changes in Retinal Vein Occlusion and Fellow Eyes by Optical Coherence Tomography Angiography: A Systematic Review and Meta-Analysis.Ophthalmology and therapy · 2025Article
- The role of optical coherence tomography angiography in assessing diabetic choroidopathy: a systematic review.International journal of retina and vitreous · 2025Review
- Macular vessel density in patients with refractory diabetic macular edema in different stages of nonproliferative diabetic retinopathy.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Article
- The Correlation Between Macular Vessel Density and Its Clinical Parameters in Diabetes Mellitus Type 2.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Sub-Clinical Regional Macular Changes in Self-Reported Diabetic Subjects: Vascular and Retinal Layer Analysis Using Swept-Source OCT.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Retinal Microvascular Changes in Association with Endothelial Glycocalyx Damage and Arterial Stiffness in Patients with Diabetes Mellitus Type 2: A Cross-Sectional Study in a Greek Population.Journal of personalized medicine · 2024Article
- Anatomical changes in idiopathic epiretinal membrane at 2-year follow-up assessed using spectral domain optical coherence tomography and optical coherence tomographic angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Early choroidal and retinal changes detected by swept-source oct in type 2 diabetes and their association with diabetic kidney disease: a longitudinal prospective study.BMC ophthalmology · 2024Article
- Biomarkers determining treatment interval of diabetic macular edema after initial resolution by anti-vascular endothelial growth factor.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Assessment of Retinal Microangiopathy in Patients with Balkan Endemic Nephropathy Using Optical Coherence Tomography Angiography-A Pilot Study.Medicina (Kaunas, Lithuania) · 2024Article
- Outer Retinal and Choroidal Changes in Adolescents with Long-Lasting Type 1 Diabetes.Journal of clinical medicine · 2023Article
- Association of Male Sex and Microvascular Alterations on Optical Coherence Tomography Angiography in Diabetes.Translational vision science & technology · 2023Article
- Review
- Macular vascular features of different types of diabetic macular edema using ocular coherence tomography angiography- a comparative study.International journal of retina and vitreous · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQuantitative assessment of vascular density (VD) of retinal and choriocapillaris (CC) in various stages of diabetic retinopathy (DR) using spectral domain optical coherence tomography angiography (SD OCTA).
methods188 eyes of 97 participants were recruited in this cross-sectional study. The macular OCTA (3x3mm) scan was performed and the computer algorithm assessed VD at the level of superficial capillary plexus (SCP), deep capillary plexus (DCP) and CC.
resultsAll measured parameters were decreased in retinal VD at the more extreme stages of DR, with the exception of SCP foveal VD. There was a constant pattern of decrease in VD of CC from normal cases to cases of NDR and NPDR and then a slight increase occurred in the PDR stage but never touching the normal quantities. Age, fasting blood sugar, and years of diabetes mellitus were correlated with reduced VD in different segments. Multivariate linear regression analysis showed that best-corrected visual acuity (BCVA) was positively correlated with parafoveal VD at SCP and VD of foveal area at CC. VD of all subfields of macular area except foveal DCP VD showed reduced levels in diabetic macular edema (DME) patients compared to those without DME.
conclusionsThe findings of the study endorse retina VD changes as a potential biomarker for DR development before retinopathy becomes clinically evident. It seems that parafoveal VD of SCP and foveal VD of CC are good biomarkers to predict VA in the diabetic patients.
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