ArticleBMC genomics2021
High-pressure processing-induced transcriptome response during recovery of Listeria monocytogenes.
Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- High-Pressure Processing Alters Biofilm Persistence and Virulence Gene Expression inInternational journal of molecular sciences · 2026Article
- Quantitative proteomic and phenotypic responses of urinary pathogens to CuO/Cu₂O nanoparticles.Nanomedicine (London, England) · 2025Article
- Transcriptome Sequencing Reveals Distinct Stress Response of Listeria monocytogenes 6179 During Logarithmic and Stationary Growth Phases.MicrobiologyOpen · 2025Article
- Multi-omics characterization of a lytic phage targetingmSystems · 2025Article
- Prophage-mediated endolysis of Latilactobacillus Sakei TMW 1.1290 induced by exogenous stress arising from food technologies.BMC microbiology · 2025Article
- Investigating the role of theFEMS microbes · 2025Article
- High-Pressure Processing Influences Antibiotic Resistance Gene Transfer inInternational journal of molecular sciences · 2024Article
- Aquatic environment drives the emergence of cell wall-deficient dormant forms in Listeria.Nature communications · 2024Article
- Effects of intrinsic and extrinsic growth factors on virulence gene expression of foodborne pathogens in vitro and in food model systems; a review.Food science & nutrition · 2024Review
- Biological functions at high pressure: transcriptome response ofFrontiers in microbiology · 2024Article
- Impact of High-Pressure Processing (HPP) onFoods (Basel, Switzerland) · 2023Review
- Acid adaptation increased the resistance ofApplied and environmental microbiology · 2023Article
- High-Pressure Processing-Impacts on the Virulence and Antibiotic Resistance ofFoods (Basel, Switzerland) · 2023Article
- Comparative analysis of Listeria monocytogenes plasmid transcriptomes reveals common and plasmid-specific gene expression patterns and high expression of noncoding RNAs.MicrobiologyOpen · 2022Article
- Differential Proteomic Analysis ofBiology · 2022Article
- Review
- The complete genome sequence of Listeria monocytogenes strain S2542 and expression of selected genes under high-pressure processing.BMC research notes · 2021Article
- Analysis of temporal gene regulation of Listeria monocytogenes revealed distinct regulatory response modes after exposure to high pressure processing.BMC genomics · 2021Article
- A Diffusion Model to Quantify Membrane Repair Process inFrontiers in microbiology · 2021Article
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Authors and funding
16 authors.
Funding
Abstract
backgroundHigh-pressure processing (HPP) is a commonly used technique in the food industry to inactivate pathogens, including L. monocytogenes. It has been shown that L. monocytogenes is able to recover from HPP injuries and can start to grow again during long-term cold storage. To date, the gene expression profiling of L. monocytogenes during HPP damage recovery at cooling temperature has not been studied. In order identify key genes that play a role in recovery of the damage caused by HPP treatment, we performed RNA-sequencing (RNA-seq) for two L. monocytogenes strains (barotolerant RO15 and barosensitive ScottA) at nine selected time points (up to 48 h) after treatment with two pressure levels (200 and 400 MPa).
resultsThe results showed that a general stress response was activated by SigB after HPP treatment. In addition, the phosphotransferase system (PTS; mostly fructose-, mannose-, galactitol-, cellobiose-, and ascorbate-specific PTS systems), protein folding, and cobalamin biosynthesis were the most upregulated genes during HPP damage recovery. We observed that cell-division-related genes (divIC, dicIVA, ftsE, and ftsX) were downregulated. By contrast, peptidoglycan-synthesis genes (murG, murC, and pbp2A) were upregulated. This indicates that cell-wall repair occurs as a part of HPP damage recovery. We also observed that prophage genes, including anti-CRISPR genes, were induced by HPP. Interestingly, a large amount of RNA-seq data (up to 85%) was mapped to Rli47, which is a non-coding RNA that is upregulated after HPP. Thus, we predicted that Rli47 plays a role in HPP damage recovery in L. monocytogenes. Moreover, gene-deletion experiments showed that amongst peptidoglycan biosynthesis genes, pbp2A mutants are more sensitive to HPP.
conclusionsWe identified several genes and mechanisms that may play a role in recovery from HPP damage of L. monocytogenes. Our study contributes to new information on pathogen inactivation by HPP.
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