Evidence map›Paper›PMID 33579024›Full record

ArticleVaccines2021

Humoral Immunity against Measles in Mother-Infant Pairs during the First Year of Life in Greece: A Cross-Sectional Study.

Florentia Kanakoudi-Tsakalidou, Evangelia Farmaki, Eleni Papadimitriou, Anna Taparkou, Eleni Agakidou, Styliani Glykou, Fotiοs Papachristou

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Florentia Kanakoudi-Tsakalidou1st Department of Pediatrics, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokrateion General Hospital, 49 Konstantinoupoleos Str, P.C. 54246 Thessaloniki, Greece.
Evangelia Farmaki1st Department of Pediatrics, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokrateion General Hospital, 49 Konstantinoupoleos Str, P.C. 54246 Thessaloniki, Greece.
Eleni Papadimitriou1st Department of Pediatrics, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokrateion General Hospital, 49 Konstantinoupoleos Str, P.C. 54246 Thessaloniki, Greece.
Anna Taparkou1st Department of Pediatrics, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokrateion General Hospital, 49 Konstantinoupoleos Str, P.C. 54246 Thessaloniki, Greece.
Eleni Agakidou1st Department of Pediatrics, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokrateion General Hospital, 49 Konstantinoupoleos Str, P.C. 54246 Thessaloniki, Greece.ORCID 0000-0001-7361-0510
Styliani Glykou1st Department of Pediatrics, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokrateion General Hospital, 49 Konstantinoupoleos Str, P.C. 54246 Thessaloniki, Greece.ORCID 0000-0001-9833-9739
Fotiοs Papachristou1st Department of Pediatrics, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokrateion General Hospital, 49 Konstantinoupoleos Str, P.C. 54246 Thessaloniki, Greece.
Aristotle University of Thessaloniki · GR

Funding

GSK pharmaceutical Co 108378/10-09-2018
6 · The paper itself

Abstract

Measles outbreaks have surfaced in Europe during the last decades. Infants <12 months of age were the most severely affected pediatric population. The aim of this study was to investigate the duration of maternally derived measles antibodies in infants aged 1 to 12 months in relation to maternal humoral immune status and other parameters. In a prospective, cross-sectional cohort study, 124 mother/infant pairs and 63 additional infants were recruited from October 2015 through December 2019. Infants were hospitalized in a university pediatric department of a general hospital. Demographic and epidemiological data were recorded and blood samples were collected from mothers and their infants. Commercially available enzyme-linked immunosorbent assay (ELISA) was used for measuring measles antibodies. Fifty nine percent of mothers had vaccine-induced and 15% infection-acquired measles immunity. Eighty-eight percent and 94% of infants were unprotected by 5 and 10 months of age, respectively. Maternal antibody levels and infant age were significant independent predictors of infants' antibody levels whereas the method of maternal immunity acquisition, age, and origin [Greek/non-Greek] were not. Our findings suggest that about 90% of infants are susceptible to measles beyond the age of 4 months. To our knowledge, these are the first data from Greece reported under the current community composition and epidemiological conditions.

Indexed as

maternal-infant measles immunitymeasles antibodiesmeasles passive immunitymeasles susceptible infantsvaccine-induced immunitywaning measles immunity

Identifiers

PMID33579024
PMCPMC7916772
OpenAlexW3126238076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.