Differential Expression of a Panel of Ten CNTN1-Associated Genes during Prostate Cancer Progression and the Predictive Properties of the Panel Towards Prostate Cancer Relapse.

Yan Gu, Mathilda Jing Chow, Anil Kapoor, Xiaozeng Lin, Wenjuan Mei, Damu Tang

Open access · goldAbstract read

In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.6field-weighted citation impact, top 33% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

Pharmacophore based in silico study with laboratory verification-environmental explanation of prostate cancer recurrence.Environmental science and pollution research international · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yan GuDepartment of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada.

Mathilda Jing ChowDepartment of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada.

Anil KapoorDepartment of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0001-9180-8029

Xiaozeng LinDepartment of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada.

Wenjuan MeiDepartment of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada.

Damu TangDepartment of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada.

St. Joseph's Hospital · CA

Funding

CIHR

6 · The paper itself

Abstract

Contactin 1 (CNTN1) is a new oncogenic protein of prostate cancer (PC); its impact on PC remains incompletely understood. We observed CNTN1 upregulation in LNCaP cell-derived castration-resistant PCs (CRPC) and CNTN1-mediated enhancement of LNCaP cell proliferation. CNTN1 overexpression in LNCaP cells resulted in enrichment of the CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 gene set that facilitates endocrine resistance in breast cancer. The leading-edge (LE) genes (

Indexed as

Atlases as TopicCarcinogenesisCarcinoma, Renal CellCell Line, TumorCell ProliferationCohort StudiesContactin 1Databases, GeneticGene Expression Regulation, NeoplasticHumansKidney NeoplasmsMaleMultigene FamilyNeoplasm ProteinsNeoplasm Recurrence, LocalPrognosisCNTN1 protein, humanContactin 1Neoplasm ProteinsbiomarkersContactin 1prostate cancerprostate cancer recurrence

Identifiers

PMID33578925

DOI10.3390/genes12020257

PMCPMC7916715

OpenAlexW3128166013

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.