Evidence map›Paper›PMID 33578760›Full record

ArticleCells2021

Behavioural Characterisation of

Kerryanne Crawford, Peter L Oliver, Thomas Agnew, Benjamin H M Hunn, Ivan Ahel

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. BiallelicLife science alliance · 2021
    Article
  12. Peripheral Expression ofPsychiatry and clinical psychopharmacology · 2021
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kerryanne CrawfordSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Peter L OliverDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK.ORCID 0000-0003-3347-2461
Thomas AgnewSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Benjamin H M HunnDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK.
Ivan AhelSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
University of Oxford · GB

Funding

Biotechnology and Biological Sciences Research Council BB/R007195/1Cancer Research UK 22284Cancer Research UK C35050/A22284Medical Research Council MC_EX_MR/P502005/1Wellcome Trust 210634
6 · The paper itself

Abstract

Adenosine diphosphate ribosylation (ADP-ribosylation; ADPr), the addition of ADP-ribose moieties onto proteins and nucleic acids, is a highly conserved modification involved in a wide range of cellular functions, from viral defence, DNA damage response (DDR), metabolism, carcinogenesis and neurobiology. Here we study MACROD1 and MACROD2 (mono-ADP-ribosylhydrolases 1 and 2), two of the least well-understood ADPr-mono-hydrolases. MACROD1 has been reported to be largely localized to the mitochondria, while the

Indexed as

Behavior, AnimalAnimalsBody WeightCarboxylic Ester HydrolasesDNA Repair EnzymesFemaleGaitGene Knockout TechniquesGenotypeHydrolasesMaleMiceMice, KnockoutMotor ActivityReproducibility of ResultsCarboxylic Ester HydrolasesDNA Repair EnzymesHydrolasesMacrod1 protein, mouseMacrod2 protein, mouseADP-ribosylation (ADPr)behaviourgaithyperactivityMacrod2MARylation hydrolases: Macrod1motor-coordination

Identifiers

PMID33578760
PMCPMC7916507
OpenAlexW3128308817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.