Evidence map›Paper›PMID 33578743›Full record

ArticleInternational journal of molecular sciences2021

Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice.

Denise van Uden, Thomas Koudstaal, Jennifer A C van Hulst, Ingrid M Bergen, Chelsea Gootjes, Nicholas W Morrell, Geert van Loo, Jan H von der Thüsen, Thierry P P van den Bosch, Maria-Rosa Ghigna and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Dissecting the lung transcriptome of pulmonary fibrosis-associated pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  5. Review
  6. Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  7. Review
  8. Single-Cell Imaging Maps Inflammatory Cell Subsets to Pulmonary Arterial Hypertension Vasculopathy.American journal of respiratory and critical care medicine · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Smouldering fire or conflagration? An illustrated update on the concept of inflammation in pulmonary arterial hypertension.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  14. Observational
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Denise van UdenDepartment of Pulmonary Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Thomas KoudstaalDepartment of Pulmonary Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Jennifer A C van HulstDepartment of Pulmonary Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Ingrid M BergenDepartment of Pulmonary Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Chelsea GootjesDepartment of Pulmonary Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Nicholas W MorrellDepartment of Medicine, University of Cambridge & NIHR BioResource for Translational Research & Addenbrooke's Hospital NHS Foundation Trust & Royal Papworth Hospital NHS Foundation Trust, Cambridge CB2 0QQ, UK.
Geert van LooVIB Center for Inflammation Research, 9052 Ghent, Belgium.
Jan H von der ThüsenDepartment of Pathology, Erasmus MC, University Medical Center Rotterdam, 3015 GE Rotterdam, The Netherlands.ORCID 0000-0001-9699-4860
Thierry P P van den BoschDepartment of Pathology, Erasmus MC, University Medical Center Rotterdam, 3015 GE Rotterdam, The Netherlands.ORCID 0000-0002-7223-4565
Maria-Rosa GhignaSchool of Medicine, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.
Frédéric PerrosSchool of Medicine, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.ORCID 0000-0001-7730-2427
David MontaniSchool of Medicine, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.ORCID 0000-0002-9358-6922
Mirjam KoolDepartment of Pulmonary Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Karin A BoomarsDepartment of Pulmonary Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-1519-8147
Rudi W HendriksDepartment of Pulmonary Medicine, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Erasmus MC · NLInserm · FRGhent University · BEPapworth Hospital NHS Foundation Trust · GB

Funding

British Heart Foundation CH/09/001/25945Hartstichting 2016T052
6 · The paper itself

Abstract

The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is not fully understood, but evidence is accumulating that immune dysfunction plays a significant role. We previously reported that 31-week-old

Indexed as

AnimalsBone Morphogenetic Protein Receptors, Type IIDendritic CellsFamilial Primary Pulmonary HypertensionGene DeletionHeart VentriclesHumansImmunity, InnateMiceMutationToll-Like Receptor 4Tumor Necrosis Factor alpha-Induced Protein 3Bmpr2 protein, mouseBone Morphogenetic Protein Receptors, Type IITlr4 protein, mouseTnfaip3 protein, mouseToll-Like Receptor 4Tumor Necrosis Factor alpha-Induced Protein 3BMPR2dendritic cellsinflammationpulmonary arterial hypertensionTnfaip3Toll-like receptor

Identifiers

PMID33578743
PMCPMC7916474
OpenAlexW3126330989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.