Evidence map›Paper›PMID 33578728›Full record

ArticleJournal of fungi (Basel, Switzerland)2021

In Vitro and In Vivo Anti-

Tecla Ciociola, Thelma A Pertinhez, Tiziano De Simone, Walter Magliani, Elena Ferrari, Silvana Belletti, Tiziana D'Adda, Stefania Conti, Laura Giovati

Open access · goldAbstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Toxins · 2021
    Review
  7. Article
  8. In Silico Predicted Antifungal Peptides: In Vitro and In Vivo Anti-Journal of fungi (Basel, Switzerland) · 2021
    Article
  9. Antifungal Peptides.Journal of fungi (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tecla CiociolaDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0001-6499-2545
Thelma A PertinhezDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0002-3065-6567
Tiziano De SimoneDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Walter MaglianiDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Elena FerrariDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Silvana BellettiDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Tiziana D'AddaDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Stefania ContiDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0001-9973-8352
Laura GiovatiDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0001-7514-1789
University of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The previously described decapeptide AKVTMTCSAS (killer peptide, KP), derived from the variable region of a recombinant yeast killer toxin-like anti-idiotypic antibody, proved to exert a variety of antimicrobial, antiviral, and immunomodulatory activities. It also showed a peculiar self-assembly ability, likely responsible for the therapeutic effect in animal models of systemic and mucosal candidiasis. The present study analyzed the biological and structural properties of peptides derived from KP by substitution or deletion of the first residue, leaving unchanged the remaining amino acids. The investigated peptides proved to exert differential in vitro and/or in vivo anti-

Indexed as

antifungal peptidesCandida albicanscircular dichroism spectroscopyconfocal microscopyelectron microscopyGalleria mellonella modelself-assembly peptidesstructure-function relationship

Identifiers

PMID33578728
PMCPMC7916522
OpenAlexW3128957191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.