SynthesisNutrients2021
Association of Protein Intake during the Second Year of Life with Weight Gain-Related Outcomes in Childhood: A Systematic Review.
Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of early-life protein supplementation on childhood obesity and related metabolic outcomes: a systematic review and meta-analysis.The American journal of clinical nutrition · 2025Pooled it
- Apparent Saturation of Branched-Chain Amino Acid Catabolism After High Dietary Milk Protein Intake in Healthy Adults.The Journal of clinical endocrinology and metabolism · 2025Trial
- Trial
- Macronutrient intake in infancy and cardiometabolic health in preschool children from the EDEN mother-child cohort.European journal of nutrition · 2026Article
- Association between low-carbohydrate diet score and childhood obesity: a national population-based study.BMC pediatrics · 2026Article
- Clinical assessment of growth patterns, weight, and dietary management in children and adults with phenylketonuria - a retrospective study.Orphanet journal of rare diseases · 2025Article
- The Biological Value of Proteins for Pediatric Growth and Development: A Narrative Review.Nutrients · 2025Review
- Article
- Review
- Association between protein-to-energy ratio and overweight/obesity in children and adolescents in the United States: a cross-sectional study based on NHANES.Frontiers in pediatrics · 2024Article
- A repeated cross-sectional analysis of the Icelandic baby food market surveyed in 2016, 2019 and 2021.Maternal & child nutrition · 2024Article
- Dietary Intake and Body Mass Index Influence the Risk of Islet Autoimmunity in Genetically At-Risk Children: A Mediation Analysis Using the TEDDY Cohort.Pediatric diabetes · 2023Article
- Non-Dairy Animal Protein Consumption Is Positively Associated with Overweight and Obesity in Israeli Adolescents.Foods (Basel, Switzerland) · 2022Article
- Protein intake in children and growth and risk of overweight or obesity: A systematic review and meta-analysis.Food & nutrition research · 2022Review
- Complementary Feeding and Iron Status: "Nutrients · 2021Review
- Which Milk during the Second Year of Life: A Personalized Choice for a Healthy Future?Nutrients · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is accumulating evidence that early protein intake is related with weight gain in childhood. However, the evidence is mostly limited to the first year of life, whereas the high-weight-gain-velocity period extends up to about 2 years of age. We aimed to investigate whether protein intake during the second year of life is associated with higher weight gain and obesity risk later in childhood. We conducted a systematic review with searches in both PubMed
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.