Evidence map›Paper›PMID 33578665›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Serological Test to Determine Exposure to SARS-CoV-2: ELISA Based on the Receptor-Binding Domain of the Spike Protein (S-RBD

Alan Roberto Márquez-Ipiña, Everardo González-González, Iram Pablo Rodríguez-Sánchez, Itzel Montserrat Lara-Mayorga, Luis Alberto Mejía-Manzano, Mónica Gabriela Sánchez-Salazar, José Guillermo González-Valdez, Rocio Ortiz-López, Augusto Rojas-Martínez, Grissel Trujillo-de Santiago and 1 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

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  10. A magnetic bead immunoassay to detect high affinity human IgG reactive to SARS-CoV-2 Spike S1 RBD produced in Escherichia coli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Alan Roberto Márquez-IpiñaCentro de Biotecnología-FEMSA, Tecnologico de Monterrey, Monterrey CP 64849, NL, Mexico.ORCID 0000-0002-6278-5398
Everardo González-GonzálezDepartamento de Bioingeniería, Tecnologico de Monterrey, Monterrey CP 64849, NL, Mexico.ORCID 0000-0001-6588-5856
Iram Pablo Rodríguez-SánchezLaboratorio de Fisiología Molecular y Estructural, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolas de los Garza CP 66455, NL, Mexico.
Itzel Montserrat Lara-MayorgaCentro de Biotecnología-FEMSA, Tecnologico de Monterrey, Monterrey CP 64849, NL, Mexico.
Luis Alberto Mejía-ManzanoCentro de Biotecnología-FEMSA, Tecnologico de Monterrey, Monterrey CP 64849, NL, Mexico.
Mónica Gabriela Sánchez-SalazarDepartamento de Bioingeniería, Tecnologico de Monterrey, Monterrey CP 64849, NL, Mexico.
José Guillermo González-ValdezCentro de Biotecnología-FEMSA, Tecnologico de Monterrey, Monterrey CP 64849, NL, Mexico.
Rocio Ortiz-LópezTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey CP 64718, NL, Mexico.ORCID 0000-0002-7783-026X
Augusto Rojas-MartínezTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey CP 64718, NL, Mexico.
Grissel Trujillo-de SantiagoCentro de Biotecnología-FEMSA, Tecnologico de Monterrey, Monterrey CP 64849, NL, Mexico.ORCID 0000-0001-9230-4607
Mario Moisés AlvarezCentro de Biotecnología-FEMSA, Tecnologico de Monterrey, Monterrey CP 64849, NL, Mexico.
Tecnológico de Monterrey · MXUniversidad Autónoma de Nuevo León · MX

Funding

Consejo Nacional de Ciencia y Tecnología SNI 26048, SNI 256730, SNI 1056909Consejo Nacional de Ciencia y Tecnología, México Graduate Student ScholarshipsFederico Baur Endowed Chair in Nanotechnology 0020240I03Tecnológico de Monterrey 002EICIS01
6 · The paper itself

Abstract

Massive worldwide serological testing for SARS-CoV-2 is needed to determine the extent of virus exposure in a particular region, the ratio of symptomatic to asymptomatic infected persons, and the duration and extent of immunity after infection. To achieve this, the development and production of reliable and cost-effective SARS-CoV-2 antigens is critical. We report the bacterial production of the peptide S-RBD

Indexed as

antigenCOVID-19ELISAEscherichia colireceptor binding domainSARS-CoV-2serological testingspike

Identifiers

PMID33578665
PMCPMC7916330
OpenAlexW3126401644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.