Evidence map›Paper›PMID 33578648›Full record

ReviewBrain sciences2021

Systematic Review on the Safety and Tolerability of Transcranial Direct Current Stimulation in Children and Adolescents.

Derrick Matthew Buchanan, Thomas Bogdanowicz, Neha Khanna, Guillaume Lockman-Dufour, Philippe Robaey, Amedeo D'Angiulli

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06368726 (Results of the Application of 80 Sessions of tDCS for 12 Months in Children Between 6 and 11 Years Old With Autism Spectrum Disorder With Rare Diseases, Genetic Problems or PANDAS), which is not on this map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06368726 phase1enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Results of the Application of 80 Sessions of tDCS for 12 Months in Children Between 6 and 11 Years Old With Autism Spectrum Disorder With Rare Diseases, Genetic Problems or PANDAS

TypeinterventionalSponsorSpanish Foundation for Neurometrics DevelopmentRan2024 to 2026Enrolled180ConditionsAttention, Visual Perceptual Weakness, Social Behavior, Fluency DisorderArmstDCS or Transcranial Direct Current Stimulation, Risperidone
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
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  4. Comparative efficacy of different noninvasive brain stimulation protocols on upper-extremity motor function and activities of daily living after stroke: a systematic review and network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
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  19. [Simulation study on parameter optimization of transcranial direct current stimulation based on rat brain slices].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Derrick Matthew BuchananDepartment of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.ORCID 0000-0003-4478-2844
Thomas BogdanowiczDepartment of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.
Neha KhannaDepartment of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.ORCID 0000-0003-0728-2007
Guillaume Lockman-DufourDepartment of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.
Philippe RobaeyDepartment of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.
Amedeo D'AngiulliDepartment of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.ORCID 0000-0002-8295-9850
Carleton University · CAChildren's Hospital of Eastern Ontario · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscranial direct current stimulation (tDCS) is a safe, tolerable, and acceptable technique in adults. However, there is limited evidence for its safety in youth. Although limited, there are a handful of important empirical articles that have evaluated safety and tolerability outcomes in youth. However, a synthesis of pediatric safety studies is not currently available.

objectiveTo synthesize objective evidence regarding the safety and tolerability of pediatric tDCS based on the current state of the literature.

methodsOur search and report used PRISMA guidelines. Our method systematically examined investigations purposefully designed to evaluate the safety, tolerability, and acceptability of tDCS in healthy and atypical youth that were submitted to three databases, from the beginning of the database to November 2019. Safety considerations were evaluated by studies utilizing neuroimaging, physiological changes, performance on tasks, and by analyzing reported and objective side effects; tolerability via rate of adverse events; and acceptability via rate of dropouts.

resultsWe report on 203 sham sessions, 864 active sessions up to 2 mA, and 303 active hours of stimulation in 156 children. A total of 4.4% of the active sessions were in neurotypical controls, with the other 95.6% in clinical subjects.

conclusionIn spite of the fact that the current evidence is sporadic and scarce, the presently reviewed literature provides support for the safety, tolerability, and acceptability, of tDCS in youth for 1-20 sessions of 20 min up to 2 mA. Future pediatric tDCS research is encouraged.

Indexed as

brain stimulationchildrensafetytDCStolerability

Identifiers

PMID33578648
PMCPMC7916366
OpenAlexW3128129664

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.