ArticleHaemophilia : the official journal of the World Federation of Hemophilia2021
Lower physical activity and altered body composition in patients with haemophilia compared with healthy controls.
Article in Haemophilia : the official journal of the World Federation of Hemophilia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Risk of low bone mineral density in patients with haemophilia: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2024Pooled it
- Article
- Preoperative CT-derived thigh muscle quality as a predictor of postoperative outcomes after total knee arthroplasty in patients with hemophilia.Frontiers in medicine · 2026Article
- Real-World Unmet Needs of Patients With Haemophilia A and Haemophilia B With or Without Inhibitors: End-of-Study Results From the explorer6 Non-Interventional Study.Haemophilia : the official journal of the World Federation of Hemophilia · 2025Observational
- Physical activity and handgrip strength in patients with mild, moderate and severe haemophilia: Impacts on bone quality and lean mass.PloS one · 2025Observational
- Determination of body composition by dual x-ray absorptiometry in persons with haemophilia.Haemophilia : the official journal of the World Federation of Hemophilia · 2024Article
- Efficacy of Real-Time Feedback Exercise Therapy in Patients Following Total Hip Arthroplasty: Protocol for a Pilot Cluster-Randomized Controlled Trial.JMIR research protocols · 2024Article
- Physical Activity, Bleedings and Quality of Life in Subjects with Haemophilia A without Inhibitors-A Multicenter, Observational Italian Study with a Wearable Device.Journal of clinical medicine · 2024Article
- Physical activity, physical fitness and cardiometabolic risk amongst adults with moderate and severe haemophilia.Haemophilia : the official journal of the World Federation of Hemophilia · 2023Article
- Exploration of the minimum necessary FVIII level at different physical activity levels in pediatric patients with hemophilia A.Frontiers in pediatrics · 2022Article
- Promoting Sports Practice in Persons with Hemophilia: A Survey of Clinicians' Perspective.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
introductionPatients with haemophilia (PWH) have traditionally been discouraged from engaging in sports and strenuous exercise activities, due to the perceived risk of bleeding complications. This puts PWH at an increased risk to become overweight or obese. However, the benefits of many forms of physical activity seem to outweigh their risks, although activities with significant trauma risk should be avoided.
aimTo evaluate physical activity patterns and body composition of adult PWH.
methodsThis cross-sectional study compared data on physical activity from tri-axial accelerometers and body composition of 18 male adult PWH (aged 18-49 years) on prophylactic replacement therapy and without acute joint bleedings to those of 24 healthy age-matched controls, by means of Mann-Whitney-U-Tests.
resultsMedian moderate-to-vigorous physical activity was significantly (p = .000) lower in PWH (34.6 min/day) than in healthy controls (65.2 min/day). Body mass index was almost similar between PWH and controls (25.1 vs 24.2 kg/m
conclusionAlthough physical activity has been recommended for PWH since the mid-1970s, the physical activity engagement of adult PWH was still severely limited, possibly due to over-cautiousness but presumably also in consequence of chronic pain. Poor physical activity engagement may well be expected to contribute to the increased body fat and decreased leg muscle mass. Consequently, policies should focus on improving the knowledge and motivation of PWH to engage in health-enhancing physical activity.
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Registered trials
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