ArticlePsychiatry research2021
Risk factors for natural cause mortality in a cohort of 1494 persons with serious mental illness.
Article in Psychiatry research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Efficacy, Acceptability, and Feasibility of StayQuit for Sustaining Smoking Abstinence After Psychiatric Hospitalization: A Pilot Study.Journal of patient-centered research and reviews · 2026Article
- [Factors Influencing All-Cause and Specific-Cause Deaths Among Community-Dwelling Schizophrenia Patients in a Region of Western China].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Risk factors for unnatural mortality in persons with serious mental illness.Scientific reports · 2025Article
- All-cause and cause-specific mortality in people with depression: a large-scale systematic review and meta-analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Altered gut microbial diversity, composition, and metabolomic potential in patients with major depressive disorder and recent suicide attempt.Brain, behavior, & immunity - health · 2025Article
- (Cost-)effectiveness and implementation of a combined lifestyle intervention for outpatients with severe mental illness (GOAL!): a hybrid quasi-experimental study protocol.BMC psychiatry · 2024Article
- Risk Factors for Natural Cause Mortality in Schizophrenia.JAMA network open · 2024Article
- Tobacco smoking and nicotine vaping in persons with first episode psychosis.Schizophrenia research · 2024Article
- Mortality in Qatari individuals with mental illness: a retrospective cohort study.Annals of general psychiatry · 2024Article
- Measuring the digital divide among people with severe mental ill health using the essential digital skills framework.Perspectives in public health · 2024Review
- Life expectancy and years of potential life lost in people with mental disorders: a systematic review and meta-analysis.EClinicalMedicine · 2023Article
- Digital health literacy and digital engagement for people with severe mental ill health across the course of the COVID-19 pandemic in England.BMC medical informatics and decision making · 2023Article
- Promoting Evidence-Based Tobacco Cessation Treatment in Community Mental Health Clinics: Protocol for a Prepost Intervention Study.JMIR research protocols · 2023Article
- Heightened inflammation in bipolar disorder occurs independent of symptom severity and is explained by body mass index.Brain, behavior, & immunity - health · 2023Article
- Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022Article
- Use of the Internet and Digital Devices Among People With Severe Mental Ill Health During the COVID-19 Pandemic Restrictions.Frontiers in psychiatry · 2021Article
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Authors and funding
11 authors.
Funding
Abstract
Persons with serious mental illness die on average more than 10 years younger than those in the overall population, mostly due to natural causes. Previous studies have identified predictors of natural cause mortality in this population but few have been prospective studies using clinical variables from in-person evaluations. A cohort of 1494 individuals with schizophrenia, bipolar disorder, or major depressive disorder were assessed at baseline and mortality status was determined from the US National Death Index after up to 20 years of follow-up. Analyses included multivariate Cox proportional hazard models to determine independent predictors of natural cause mortality. A total of 125 (8.4%) individuals died of natural causes. In multivariate models, the strongest predictor of mortality after age was tobacco smoking at baseline with a dose-related effect. Having diabetes, a cardiovascular condition, particularly hypertension, and lower cognitive functioning were also significant risks, along with divorced/separated status. The receipt of gabapentin or fluoxetine also significantly increased mortality risk. Premature death can be reduced by smoking cessation and the improved management of conditions such as hypertension and diabetes.
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