ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021
Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Leishmaniasis in deployed military populations: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- IgG3 and IL10 are effective biomarkers for monitoring therapeutic effectiveness in Post Kala-Azar Dermal Leishmaniasis.PLoS neglected tropical diseases · 2021Trial
- Systemic IgG responses toFrontiers in immunology · 2026Article
- Disseminated Leishmaniasis, a Severe Form of Leishmania braziliensis Infection.Emerging infectious diseases · 2024Article
- Dogs HarborPathogens (Basel, Switzerland) · 2023Article
- Immune Response to LinB13, a Lutzomyia Intermedia Salivary Protein Correlates With Disease Severity in Tegumentary Leishmaniasis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- ELISA-based evaluation of antibody response to Leishmania in a region endemic for cutaneous leishmaniasis.Parasite immunology · 2022Article
- Validation of an In-House ELISA Method in the Diagnosis of Cutaneous Leishmaniasis Caused byMicroorganisms · 2022Article
- Protection and Pathology inPathogens (Basel, Switzerland) · 2022Review
- Immunological biomarkers and their role in the diagnosis and prognosis of leishmaniasis: A case-control study.Tropical parasitologyArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn this study, we determined the accuracy of anti-Leishmania IgG and IgG subclasses to distinguish clinical forms of American tegumentary leishmaniasis (ATL) and and determined the relationship between antibodies levels with cytokine production and severity of ATL.
methodsParticipants were 40 patients with cutaneous leishmaniasis (CL), 20 patients with mucosal leishmaniasis (ML), 20 patients with disseminated leishmaniasis (DL), and 20 individuals with subclinical Leishmania braziliensis infection (SC). Diagnosis was performed by DNA of L. braziliensis or IFN-γ production in SC. IgG and subclasses of IgG to soluble Leishmania antigen and cytokine levels in supernatants of mononuclear cells were detected by ELISA.
resultsIgG was detected in 95%, 95%, and 100% of patients with CL, ML, and DL, respectively. Higher levels of anti-Leishmania IgG and IgG2 were seen in DL compared to CL, ML, and SC. ROC analysis confirmed the ability of IgG to distinguish DL from the other clinical forms. A direct correlation was observed between IgG titers and levels of IFN-γ and CXCL10 in CL and DL, and IgG2 antibodies were correlated with the number of lesions in DL.
conclusionsHigh anti-Leishmania IgG and IgG2 levels are characteristic of DL, and while IgG was correlated with pro-inflammatory cytokines, IgG2 was direct correlated with the number of lesions.
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