Evidence map›Paper›PMID 33577969›Full record

ArticleNeurotoxicology and teratology

A sibling-comparison study of smoking during pregnancy and risk for reading-related problems.

Lauren Micalizzi, Kristine Marceau, Allison S Evans, Leslie A Brick, Rohan H C Palmer, Andrew C Heath, Valerie S Knopik

Abstract read
In one paragraph

Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lauren MicalizziCenter for Alcohol and Addiction Studies, Brown University School of Public Health, Box G-S121-5, Providence, RI 02903, United States of America. Electronic address: lauren_micalizzi@brown.edu.
Kristine MarceauDepartment of Human Development and Family Studies, Purdue University, 1202 W State Street, West Lafayette, IN 47907, United States of America.
Allison S EvansConcord Comprehensive Neuropsychological Services, 86 Baker Avenue Extension #301, Concord, MA 01742, United States of America.
Leslie A BrickDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, 345 Blackstone Blvd, Providence, RI 02906, United States of America.
Rohan H C PalmerBehavioral Genetics of Addiction Laboratory, Department of Psychology, Emory University, 36 Eagle Row, Atlanta, GA 30322, United States of America.
Andrew C HeathMidwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO 63110, United States of America.
Valerie S KnopikDepartment of Human Development and Family Studies, Purdue University, 1202 W State Street, West Lafayette, IN 47907, United States of America.

Funding

PILOT--GENETIC EPIDEMIOLOGY OF ALCOHOL AND TOBACCO CONSUMPTION IN CHINESE SAMPLEP50AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI SHER, KENNETH JAMES · 1999 to 2008
$12.6M
Resource CoreP60AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN · 2009 to 2013
$8.8M
ALCOHOLISM: GENETIC EPIDEMIOLOGIC TWIN STUDYR01AA009022 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1994 to 2004
$3.3M
GxE in Early Childhood: Twin MothersR01HD049024 · NICHD · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2005 to 2009
$2.9M
Prenatal tobacco exposure: effects on neuropsychological outcomes and ADHDR01DA023134 · NIDA · RHODE ISLAND HOSPITAL · PI KNOPIK, VALERIE S · 2008 to 2013
$2.7M
Genetic Epideniologic Models of Alcohol AbuseR37AA007728 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1998 to 2007
$2.2M
GENE-ENVIRONMENT INTERPLAY IN ALCOHOLISMK05AA017688 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2008 to 2017
$1.9M
Integrative Prioritization of Alcohol and Drug-Addiction Related Genetic LociR01DA042742 · NIDA · EMORY UNIVERSITY · PI PALMER, ROHAN HUGH CRAIG · 2018 to 2022
$1.7M
NEIGHBORHOOD, FAMILY AND INDIVIDUAL FACTORS IN ADOLESCENT DRINKINGR01AA021492 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C., SCHOOTMAN, MARIO · 2013 to 2016
$1.2M
Prenatal Tobacco Exposure: Self-Regulatory Pathways to Externalizing BehaviorsK01DA048135 · NIDA · BROWN UNIVERSITY · PI MICALIZZI, LAUREN GIOIA · 2020 to 2024
$905k
Bio-behavioral Developmental Origins of Adolescent Substance AbuseK01DA039288 · NIDA · PURDUE UNIVERSITY · PI MARCEAU, KRISTINE · 2016 to 2020
$876k
Externalizing Behavior: Genetics x Prenatal NicotineK01DA017671 · NIDA · WASHINGTON UNIVERSITY · PI KNOPIK, VALERIE S · 2004 to 2008
$813k
NCATS NIH HHS L30 TR001045NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P50 AA011998NIAAA NIH HHS P60 AA011998NIAAA NIH HHS R01 AA009022NIAAA NIH HHS R01 AA021492NIAAA NIH HHS R37 AA007728NICHD NIH HHS R01 HD049024NIDA NIH HHS K01 DA017671NIDA NIH HHS K01 DA039288NIDA NIH HHS K01 DA048135NIDA NIH HHS R01 DA023134NIDA NIH HHS R01 DA042742
6 · The paper itself

Abstract

This research examines the relationship between smoking during pregnancy (SDP) and risk for reading related problems in siblings discordant for exposure to SDP. Data (N = 173 families) were drawn from the Missouri Mothers and Their Children study, a sample, identified using birth records (years 1998-2005), in which mothers changed her smoking behavior between two pregnancies (Child 1 [older sibling]: M = 12.99; Child 2 [younger sibling]: M = 10.19). A sibling comparison approach was used, providing a robust test for the association between SDP and reading related outcomes in school-aged children. Results suggested within-family (i.e., potentially causal) associations between SDP and reading and language/comprehension factor scores, as well as between SDP and specific reading-related skills, including reading accuracy and receptive language, with increased exposure to SDP associated with decreased performance. SDP was not associated with spelling, reading rate, or receptive vocabulary. Initial within-family associations between SDP and word-letter identification, phonetic/decoding skills, and reading comprehension were fully attenuated following partial control for genetic and environmental confounding of the associations. These findings indicate that exposure to SDP is associated with poorer performance on some, but not all skills assessed.

Indexed as

AdultComprehensionDyslexiaFemaleHumansLanguage TestsMaleMothersPregnancyPrenatal Exposure Delayed EffectsPsychomotor PerformanceReadingSiblingsSmoking CessationTobacco SmokingVocabularyFamily studiesLanguageReadingSmoking during pregnancy

Identifiers

PMID33577969
PMCPMC7965354

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.