Evidence map›Paper›PMID 33577909›Full record

ReviewProgress in lipid research2021

Antibacterial fatty acids: An update of possible mechanisms of action and implications in the development of the next-generation of antibacterial agents.

Giancarlo Casillas-Vargas, Carlimar Ocasio-Malavé, Solymar Medina, Christian Morales-Guzmán, René García Del Valle, Néstor M Carballeira, David J Sanabria-Ríos

Open access · hybridAbstract readReview
In one paragraph

Review in Progress in lipid research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed
39.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 471 citations in OpenAlex.

  1. Article
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  8. Pharmacological basis for the traditional use ofJournal of traditional and complementary medicine · 2026
    Article
  9. Lauric Acid Microemulsions InhibitFoods (Basel, Switzerland) · 2026
    Article
  10. Supercritical COMolecules (Basel, Switzerland) · 2026
    Article
  11. Article
  12. Article
  13. Review
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  15. Article
  16. Phytochemical Analysis and Bioactivities ofPlants (Basel, Switzerland) · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Giancarlo Casillas-VargasFaculty of Science and Technology, Department of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, USA.
Carlimar Ocasio-MalavéFaculty of Science and Technology, Department of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, USA.
Solymar MedinaFaculty of Science and Technology, Department of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, USA.
Christian Morales-GuzmánUniversity of Puerto Rico, Río Piedras Campus, Department of Chemistry, 17 Ave. Universidad Ste. 1701, San Juan, PR 00925-2537, USA.
René García Del ValleUniversity of Puerto Rico, Río Piedras Campus, Department of Chemistry, 17 Ave. Universidad Ste. 1701, San Juan, PR 00925-2537, USA.
Néstor M CarballeiraUniversity of Puerto Rico, Río Piedras Campus, Department of Chemistry, 17 Ave. Universidad Ste. 1701, San Juan, PR 00925-2537, USA. Electronic address: nestor.carballeira1@upr.edu.
David J Sanabria-RíosFaculty of Science and Technology, Department of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, USA. Electronic address: dsanabria@intermetro.edu.
InterAmerican University of Puerto Rico · PRUniversity of Puerto Rico at Río Piedras · PR

Funding

SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Jose R. Rodriguez-Medina · 2012 to 2026
$52.9M
Upgrade Laboratories Facilities at UPR-Rio PiedrasR25GM061151 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 2001 to 2023
$32.5M
NIGMS NIH HHS P20 GM103475NIGMS NIH HHS R25 GM061151
6 · The paper itself

Abstract

The antibacterial activity of fatty acids (FA) is well known in the literature and represents a promising option for developing the next-generation of antibacterial agents to treat a broad spectrum of bacterial infections. FA are highly involved in living organisms' defense system against numerous pathogens, including multidrug-resistant bacteria. When combined with other antibacterial agents, the remarkable ability of FA to enhance their bactericidal properties is a critical feature that is not commonly observed in other naturally-occurring compounds. More reviews focusing on FA antibacterial activity, traditional and non-traditional mechanisms and biomedical applications are needed. This review is intended to update the reader on the antibacterial properties of recent FA and how their chemical structures influence their antibacterial activity. This review also aims to better understand both traditional and non-traditional mechanisms involved in these recently explored FA antibacterial activities.

Indexed as

Anti-Bacterial AgentsFatty AcidsAnti-Bacterial AgentsFatty AcidsAntibacterial agentsFA mechanismsFatty acidsMultidrug-resistant bacteriaNon-traditional antibacterial

Identifiers

PMID33577909
PMCPMC8137538
OpenAlexW3127726407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.