Evidence map›Paper›PMID 33577882›Full record

ArticleBehavioural brain research2021

Chronic antipsychotic treatment exerts limited effects on the mania-like behavior of dopamine transporter knockdown mice.

Zackary A Cope, Johnny A Kenton, Arpi Minassian, Maureen V Martin, William Perry, Christoffer Bundgaard, Jørn Arnt, Jordy van Enkhuizen, Mark A Geyer, Jared W Young

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Zackary A CopeDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, United States.
Johnny A KentonDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, United States.
Arpi MinassianDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, United States; Center of Excellence for Stress and Mental Health and Research Service, VA San Diego Healthcare System, United States.
Maureen V MartinDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, United States.
William PerryDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, United States.
Christoffer BundgaardH. Lundbeck A/S. Neuroscience Research, Ottiliavej 9, DK-2500, Copenhagen, Valby, Denmark.
Jørn ArntSunred Pharma Consulting, Solrød Strand, Denmark.
Jordy van EnkhuizenDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, United States.
Mark A GeyerDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, United States; Research Service, VA San Diego Healthcare System, San Diego, CA, United States.
Jared W YoungDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, United States; Research Service, VA San Diego Healthcare System, San Diego, CA, United States. Electronic address: jaredyoung@ucsd.edu.
University of California, San Diego · USVA San Diego Healthcare System · USLundbeck (Denmark) · DK

Funding

Cannabis use and the endocannabinoid system in bipolar disorderR01DA043535 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PERRY, WILLIAM, YOUNG, JARED WILLIAM · 2018 to 2022
$3.3M
A model organism of brain circuitry and behavioral switching for bipolar disorderR01MH104344 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YOUNG, JARED WILLIAM · 2014 to 2017
$1.7M
NIDA NIH HHS R01 DA043535NIMH NIH HHS R01 MH104344
6 · The paper itself

Abstract

backgroundBipolar disorder is a life-threatening disorder linked to dopamine transporter (DAT) polymorphisms, with reduced DAT levels seen in positron emission tomography and postmortem brains.

aimsThe purpose of this study was to examine the effects of approved antipsychotics on DAT dysfunction-mediated mania behavior in mice.

methodsDAT knockdown mice received either D

resultsChronic risperidone did not reverse mania-like behavior in DAT knockdown mice. Chronic asenapine reduced mania behavior but this effect was more pronounced in wild-type littermates than in DAT knockdown mice.

conclusionTaken together, these findings suggest that while acute antipsychotic treatment may be beneficial in management of bipolar mania, more targeted therapeutics may be necessary for long-term treatment. Specific investigation into DAT-targeting drugs could improve future treatment of bipolar mania.

Indexed as

AnimalsAntipsychotic AgentsBehavior, AnimalBipolar DisorderDibenzocycloheptenesDisease Models, AnimalDopamine D2 Receptor AntagonistsDopamine Plasma Membrane Transport ProteinsFemaleMaleManiaMiceMice, 129 StrainMice, Inbred C57BLMice, TransgenicRisperidoneAntipsychotic AgentsasenapineDibenzocycloheptenesDopamine D2 Receptor AntagonistsDopamine Plasma Membrane Transport ProteinsRisperidoneAntipsychoticBehavioral pattern monitorBipolar disorderDopamine transporterManiaMice

Identifiers

PMID33577882
PMCPMC10729608
OpenAlexW3128476067

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.