Evidence map›Paper›PMID 33577623›Full record

ArticlePloS one2021

Metabolomic analysis of uremic pruritus in patients on hemodialysis.

Christian G Bolanos, Nhat M Pham, Robert D Mair, Timothy W Meyer, Tammy L Sirich

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  12. Observational
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  16. Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024
    Article
  17. Review
  18. Uremic Pruritus: From Diagnosis to Treatment.Diagnostics (Basel, Switzerland) · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Christian G BolanosThe Department of Medicine, Stanford University, Palo Alto, California, United States of America.
Nhat M PhamThe Department of Medicine, Stanford University, Palo Alto, California, United States of America.
Robert D MairThe Department of Medicine, Stanford University, Palo Alto, California, United States of America.
Timothy W MeyerThe Department of Medicine, Stanford University, Palo Alto, California, United States of America.
Tammy L SirichThe Department of Medicine, Stanford University, Palo Alto, California, United States of America.ORCID 0000-0001-5587-8193
VA Palo Alto Health Care System · USSanta Clara Valley Medical Center · US

Funding

Dietary and Microbial Reprogramming of Intestinal Microbiota-Produced MetabolitesR01DK101674 · NIDDK · STANFORD UNIVERSITY · PI FISCHBACH, MICHAEL ANDREW, MEYER, TIMOTHY W · 2014 to 2024
$6.5M
The Colon Microbiome in Dialysis PatientsF32DK111166 · NIDDK · STANFORD UNIVERSITY · PI MAIR, ROBERT DEWOLFE · 2016 to 2018
$190k
New Solutes to Assess Kidney DiseaseIK2CX001036 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI SIRICH, TAMMY LISA · 2014 to 2018
–
CSRD VA IK2 CX001036NIDDK NIH HHS F32 DK111166NIDDK NIH HHS R01 DK101674
6 · The paper itself

Abstract

Pruritus is a common debilitating symptom experienced by hemodialysis patients. Treatment is difficult because the cause of uremic pruritus is not known. This study addressed the hypothesis that pruritus is caused by solutes that accumulate in the plasma when the kidneys fail. We sought to identify solutes responsible for uremic pruritus using metabolomic analysis to compare the plasma of hemodialysis patients with severe pruritus versus mild/no pruritus. Pruritus severity in hemodialysis patients was assessed using a 100-mm visual analogue scale (VAS), with severe pruritus defined as >70 mm and mild/no pruritus defined as <10 mm. Twelve patients with severe pruritus (Itch) and 24 patients with mild/no pruritus (No Itch) were included. Pre-treatment plasma and plasma ultrafiltrate were analyzed using an established metabolomic platform (Metabolon, Inc.). To identify solutes associated with pruritus, we compared the average peak area of each solute in the Itch patients to that of the No Itch patients using the false discovery rate (q value) and principal component analysis. Dialysis vintage, Kt/Vurea, and serum levels of calcium, phosphorus, PTH, albumin, ferritin, and hemoglobin were similar in the Itch and No Itch patients. Metabolomic analysis identified 1,548 solutes of which 609 were classified as uremic. No difference in the plasma or plasma ultrafiltrate levels of any solute or group of solutes was found between the Itch and No Itch patients. Metabolomic analysis of hemodialysis patients did not reveal any solutes associated with pruritus. A limitation of metabolomic analysis is that the solute of interest may not be included in the metabolomic platform's chemical library. A role for uremic solutes in pruritus remains to be established.

Indexed as

AgedAlbuminsCalciumFemaleFerritinsHemoglobinsHumansKidneyMaleMetabolomeMetabolomicsMiddle AgedPhosphorusPrincipal Component AnalysisPruritusRenal DialysisAlbuminsCalciumFerritinsHemoglobinsPhosphorus

Identifiers

PMID33577623
PMCPMC7880487
OpenAlexW3126796767

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.