ArticlePloS one2021
Total plaque score helps to determine follow-up strategy for carotid artery stenosis progression in head and neck cancer patients after radiation therapy.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Interventions for head and neck cancer survivors: Systematic review.Head & neck · 2022Pooled it
- Diagnostic Performance of Duplex Ultrasonography in Post-Radiation Common Carotid Artery Stenosis: A Cross-Sectional Validation Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Radiation-Induced Carotid Artery Disease: Pathogenesis, Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2026Review
- The impact of different types of radiotherapy on cerebrovascular-specific death in patients with thyroid malignant tumors.Discover oncology · 2025Article
- Post-irradiation vertebral and carotid stenosis heightens stroke risk in head and neck cancer.BMC cancer · 2025Observational
- Carotid artery stenosis and ischemic cerebrovascular events after radiotherapy in patients with head and neck cancer.PloS one · 2025Article
- Radiation Vasculopathy.Cerebrovascular diseases extra · 2025Review
- Radiation Dose-Induced Carotid Artery Stenosis and Brain Necrosis in Head and Neck Cancer-A Real World Cohort Study.Cancers · 2024Article
- Article
- Application of Carotid Duplex Ultrasonography in the Surveillance of Carotid Artery Stenosis after Neck Irradiation.Reviews in cardiovascular medicine · 2022Review
- Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo identify predictors of carotid artery stenosis (CAS) progression in head and neck cancer (HNC) patients after radiation therapy (RT).
methodsWe included 217 stroke-naïve HNC patients with mild carotid artery stenosis after RT in our hospital. These patients underwent annual carotid duplex ultrasound (CDU) studies to monitor CAS progression. CAS progression was defined as the presence of ≥50% stenosis of the internal/common carotid artery on follow-up CDU. We recorded total plaque score (TPS) and determined the cut-off TPS to predict CAS progression. We categorized patients into high (HP) and low plaque (LP) score groups based on their TPS at enrolment. We analyzed the cumulative events of CAS progression in the two groups.
resultsThe TPS of the CDU study at enrolment was a significant predictor for CAS progression (adjusted odds ratio [aOR] = 1.69, p = 0.002). The cut-off TPS was 7 (area under the curve: 0.800), and a TPS ≥ 7 strongly predicted upcoming CAS progression (aOR = 41.106, p = 0.002). The HP group had a higher risk of CAS progression during follow-up (adjusted hazard ratio = 6.15; 95% confident interval: 2.29-16.53) in multivariable Cox analysis, and also a higher trend of upcoming ischemic stroke (HP vs. LP: 8.3% vs. 2.2%, p = 0.09).
conclusionsHNC patients with a TPS ≥ 7 in any CDU study after RT are susceptible to CAS progression and should receive close monitoring within the following 2 years.
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