Evidence map›Paper›PMID 33577436›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Left ventricular diastolic dysfunction and exercise intolerance in obese heart failure with preserved ejection fraction.

T Jake Samuel, Dalane W Kitzman, Mark J Haykowsky, Bharathi Upadhya, Peter Brubaker, M Benjamin Nelson, W Gregory Hundley, Michael D Nelson

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

T Jake SamuelDepartment of Kinesiology, University of Texas at Arlington, Arlington, Texas.ORCID 0000-0001-7638-1864
Dalane W KitzmanSection on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina.
Mark J HaykowskyFaculty of Nursing, University of Alberta, Edmonton, Alberta, Canada.
Bharathi UpadhyaSection on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina.
Peter BrubakerDepartment of Health and Exercise Science, Wake Forest University, North Carolina.
M Benjamin NelsonSection on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina.
W Gregory HundleyInternal Medicine, Virginia Commonwealth University, Richmond, Virginia.
Michael D NelsonDepartment of Kinesiology, University of Texas at Arlington, Arlington, Texas.
The University of Texas at Arlington · USWake Forest University · USVirginia Commonwealth University · USUniversity of Alberta · CA

Funding

TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI PETER J HORNSBY · 1995 to 2026
$30.6M
Targeting skeletal muscle to improve exercise capacity in heart failure with preserved ejection fraction.P01HL137630 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI LEVINE, BENJAMIN D · 2019 to 2023
$11.4M
REHAB-HF: A Trial of Rehabilitation Therapy in Older Acute Heart Failure PatientsR01AG045551 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2014 to 2018
$6.8M
Pepper OAIC Coordinating CenterU24AG059624 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DALANE W KITZMAN · 2018 to 2026
$6.0M
Exercise Intolerance in Older HFPEF PatientsR01AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2001 to 2019
$5.2M
A Multidisciplinary Analysis of Gelsolin Amyloid DiseaseR01AG018917 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI KELLY, JEFFERY W · 2002 to 2010
$4.2M
Mechanism and Modulation of Sex Differences in Myocardial Steatosis Induced Left Ventricular DysfunctionR01HL136601 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI NELSON, MICHAEL DOUGLAS · 2018 to 2022
$3.3M
SPRINT - HeartR01HL107257 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2011 to 2014
$1.5M
NHLBI NIH HHS P01 HL137630NHLBI NIH HHS R01 HL107257NHLBI NIH HHS R01 HL136601NIA NIH HHS P30 AG013319NIA NIH HHS R01 AG018915NIA NIH HHS R01 AG018917NIA NIH HHS R01 AG045551NIA NIH HHS U24 AG059624
6 · The paper itself

Abstract

This study tested the hypothesis that early left ventricular (LV) relaxation is impaired in older obese patients with heart failure with preserved ejection fraction (HFpEF), and related to decreased peak exercise oxygen uptake (peak V̇o

Indexed as

Exercise ToleranceStroke VolumeVentricular Function, LeftAgedCase-Control StudiesDiastoleEchocardiography, DopplerExercise TestFemaleHeart FailureHumansMagnetic Resonance ImagingMaleMiddle AgedObesityOxygen Consumptiondiastolic dysfunctionexercise intoleranceheart failureheart failure with preserved ejection fractionobesity

Identifiers

PMID33577436
PMCPMC8260389
OpenAlexW3128218931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.