Evidence map›Paper›PMID 33576924›Full record

SynthesisClinical rheumatology2021

Does current evidence on disease-modifying antirheumatic drugs for psoriatic arthritis reinforce an effect on radiographic progression? Results from a systematic review and meta-analysis.

Mariana Garcia-Leal, Mayra A Reyes-Soto, Ivan Hernandez-Galarza, Neri A Alvarez-Villalobos, Dionicio A Galarza-Delgado, Diana E Flores-Alvarado

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Mariana Garcia-LealPlataforma INVEST Medicina UANL-KER Unit Mayo Clinic (KER Unit Mexico), Universidad Autonoma de Nuevo Leon, 64460, Monterrey, Mexico.ORCID https://orcid.org/0000-0002-6778-5119
Mayra A Reyes-SotoRheumatology Division, Department of Internal Medicine, University Hospital "Dr. José E. González", Universidad Autonoma de Nuevo Leon, Gonzalitos 235 Norte, Mitras Centro, 64020, Monterrey, Mexico.ORCID https://orcid.org/0000-0001-9433-5976
Ivan Hernandez-GalarzaRheumatology Division, Department of Internal Medicine, University Hospital "Dr. José E. González", Universidad Autonoma de Nuevo Leon, Gonzalitos 235 Norte, Mitras Centro, 64020, Monterrey, Mexico.ORCID https://orcid.org/0000-0001-9597-8789
Neri A Alvarez-VillalobosPlataforma INVEST Medicina UANL-KER Unit Mayo Clinic (KER Unit Mexico), Universidad Autonoma de Nuevo Leon, 64460, Monterrey, Mexico.ORCID https://orcid.org/0000-0001-5208-1429
Dionicio A Galarza-DelgadoRheumatology Division, Department of Internal Medicine, University Hospital "Dr. José E. González", Universidad Autonoma de Nuevo Leon, Gonzalitos 235 Norte, Mitras Centro, 64020, Monterrey, Mexico.ORCID https://orcid.org/0000-0001-9714-2109
Diana E Flores-AlvaradoRheumatology Division, Department of Internal Medicine, University Hospital "Dr. José E. González", Universidad Autonoma de Nuevo Leon, Gonzalitos 235 Norte, Mitras Centro, 64020, Monterrey, Mexico. anaidflores@hotmail.com.ORCID http://orcid.org/0000-0003-1181-4977
Universidad Autónoma de Nuevo León · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to estimate the effect of synthetic and biologic disease-modifying antirheumatic drugs (DMARDs) on radiographic progression and quality of life in adult patients with psoriatic arthritis. A comprehensive search was performed using MEDLINE, Embase, Web of Science, Scopus, and Cochrane Central Register of Controlled Trials (CCRCT). Clinical trials comparing DMARDs with placebo for ≥ 12 weeks were included. The meta-analysis was conducted with a random-effects model using mean differences (MD). A total of 16 trials with overall moderate quality of evidence were included. Exposure to a biologic agent reduced radiographic progression at 24 weeks of treatment (MD: - 0.66; [95% CI - 0.97 to - 0.34]; P < .00001; I

Indexed as

Antirheumatic AgentsArthritis, PsoriaticAdultAntibodies, MonoclonalHumansInterleukin-12Quality of LifeAntibodies, MonoclonalAntirheumatic AgentsInterleukin-12Biologicals, quality of lifeDisease-modifying antirheumatic drugsJoint damagePsoriatic arthritisRadiographic progression score

Identifiers

PMID33576924
OpenAlexW3126991983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.