Evidence map›Paper›PMID 33576886›Full record

ArticleApplied microbiology and biotechnology2021

Host defence peptides identified in human apolipoprotein B as promising antifungal agents.

Eliana Dell'Olmo, Rosa Gaglione, Angela Cesaro, Valeria Cafaro, Wieke R Teertstra, Hans de Cock, Eugenio Notomista, Henk P Haagsman, Edwin J A Veldhuizen, Angela Arciello

Open access · hybridAbstract read
In one paragraph

Article in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. In Vitro Activity of Novel Lipopeptides against Triazole-ResistantJournal of fungi (Basel, Switzerland) · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Emerging Antifungal Targets and Strategies.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Eliana Dell'OlmoDepartment of Chemical Sciences, University of Naples Federico II, 80126, Naples, Italy.
Rosa GaglioneDepartment of Chemical Sciences, University of Naples Federico II, 80126, Naples, Italy.
Angela CesaroDepartment of Chemical Sciences, University of Naples Federico II, 80126, Naples, Italy.
Valeria CafaroDepartment of Biology, University of Naples Federico II, 80126, Naples, Italy.
Wieke R TeertstraMolecular Microbiology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Hans de CockMolecular Microbiology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Eugenio NotomistaDepartment of Biology, University of Naples Federico II, 80126, Naples, Italy.
Henk P HaagsmanDepartment of Biomolecular Health Sciences, Division of Infectious Diseases and Immunology, Section Molecular Host Defence, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Edwin J A VeldhuizenDepartment of Biomolecular Health Sciences, Division of Infectious Diseases and Immunology, Section Molecular Host Defence, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. e.j.a.veldhuizen@uu.nl.
Angela ArcielloDepartment of Chemical Sciences, University of Naples Federico II, 80126, Naples, Italy. anarciel@unina.it.ORCID http://orcid.org/0000-0001-8269-6459
Utrecht University · NLUniversity of Naples Federico II · ITFederico II University Hospital · ITIstituto Nazionale Biostrutture e Biosistemi · ITUniversity of Applied Sciences Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic options to treat invasive fungal infections are still limited. This makes the development of novel antifungal agents highly desirable. Naturally occurring antifungal peptides represent valid candidates, since they are not harmful for human cells and are endowed with a wide range of activities and their mechanism of action is different from that of conventional antifungal drugs. Here, we characterized for the first time the antifungal properties of novel peptides identified in human apolipoprotein B. ApoB-derived peptides, here named r(P)ApoB

Indexed as

Antifungal AgentsAntimicrobial Cationic PeptidesApolipoproteins BCandida albicansHumansHyphaeMicrobial Sensitivity TestsAntifungal AgentsAntimicrobial Cationic PeptidesApolipoproteins BAntifungal peptidesFungal infectionsHuman cryptidesPeptide therapeutics

Identifiers

PMID33576886
PMCPMC7907042
OpenAlexW3127985967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.