Evidence map›Paper›PMID 33576869›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2021

Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of H

Joachim Neumann, Rafaela Voss, Ulrich Laufs, Christian Werner, Ulrich Gergs

Open access · hybridAbstract read
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Contractile Effects of Glucagon in Mouse Cardiac Preparations.International journal of molecular sciences · 2025
    Article
  4. Stimulation of histamine HNaunyn-Schmiedeberg's archives of pharmacology · 2025
    Article
  5. Studies on the mechanisms of action of MR33317.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  6. Article
  7. Clonidine stimulates force of contraction via histamine HNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  8. Review
  9. Ergometrine stimulates histamine HNaunyn-Schmiedeberg's archives of pharmacology · 2023
    Article
  10. OR-1896 increases force of contraction in the isolated human atrium.Naunyn-Schmiedeberg's archives of pharmacology · 2023
    Article
  11. Article
  12. Function and Role of Histamine HPharmaceuticals (Basel, Switzerland) · 2023
    Review
  13. Article
  14. Ergotamine Stimulates Human 5-HTInternational journal of molecular sciences · 2023
    Article
  15. The Roles of Cardiovascular HFrontiers in pharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Joachim NeumannInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Str. 4, D-06112, Halle, Germany.ORCID 0000-0001-5018-3851
Rafaela VossInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Str. 4, D-06112, Halle, Germany.
Ulrich LaufsKlinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.
Christian WernerKlinik für Innere Medizin III -Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Kirrberger Straße, Geb. 41.1, D-66421, Homburg, Saar, Germany.
Ulrich GergsInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Str. 4, D-06112, Halle, Germany. ulrich.gergs@medizin.uni-halle.de.
Martin Luther University Halle-Wittenberg · DEUniversitätsklinikum des Saarlandes · DEUniversity Hospital Leipzig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histamine exerts cAMP-dependent positive inotropic effects (PIE) and positive chronotropic effects (PCE) on isolated left and right atria, respectively, of transgenic mice which overexpress the human H

Indexed as

AdenineAnimalsCyclic Nucleotide Phosphodiesterases, Type 2Cyclic Nucleotide Phosphodiesterases, Type 3Cyclic Nucleotide Phosphodiesterases, Type 4FemaleHeart AtriaHeart RateHistamineHumansMaleMiceMice, TransgenicPhosphodiesterase InhibitorsQuinolonesReceptors, Histamine H29-(2-hydroxy-3-nonyl)adenineAdeninecilostamideCyclic Nucleotide Phosphodiesterases, Type 2Cyclic Nucleotide Phosphodiesterases, Type 3Cyclic Nucleotide Phosphodiesterases, Type 4HistaminePhosphodiesterase InhibitorsQuinolonesReceptors, Histamine H2RolipramChronotropyH2-histamine receptorHistamineInotropyPhosphodiesteraseTransgenic mice

Identifiers

PMID33576869
PMCPMC8208929
OpenAlexW3127960347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.