Evidence map›Paper›PMID 33576837›Full record

Trial reportInflammation research : official journal of the European Histamine Research Society ... [et al.]2021

Potential of anthocyanin as an anti-inflammatory agent: a human clinical trial on type 2 diabetic, diabetic at-risk and healthy adults.

Elham Nikbakht, Indu Singh, Jelena Vider, Lauren T Williams, Lada Vugic, Almottesembellah Gaiz, Avinash Reddy Kundur, Natalie Colson

Open access · greenAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Increased Circulating Interleukin Concentrations in Type 2 Diabetes: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
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  13. Rapid recovery of homozygousFrontiers in plant science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Elham NikbakhtSchool of Medical Science, Griffith University, Gold Coast, QLD, Australia.
Indu SinghSchool of Medical Science, Griffith University, Gold Coast, QLD, Australia.
Jelena ViderSchool of Medical Science, Griffith University, Gold Coast, QLD, Australia.
Lauren T WilliamsSchool of Allied Health Sciences, Griffith University, Gold Coast, QLD, Australia.
Lada VugicSchool of Medical Science, Griffith University, Gold Coast, QLD, Australia.
Almottesembellah GaizSchool of Medical Science, Griffith University, Gold Coast, QLD, Australia.
Avinash Reddy KundurSchool of Medical Science, Griffith University, Gold Coast, QLD, Australia.
Natalie ColsonSchool of Medical Science, Griffith University, Gold Coast, QLD, Australia. N.Colson@Griffith.edu.au.ORCID http://orcid.org/0000-0001-7883-2219
Griffith University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe present research aimed to investigate the anti-inflammatory potential of dietary anthocyanin (ACN) in type 2 diabetic (T2D), T2D-at-risk and healthy individuals. Furthermore, dietary inflammatory index (DII) was used to study the association of diet with biomarkers of inflammation. RESEARCH

methodsAn open-label clinical trial was conducted at Griffith University investigating the efficacy of 320 mg ACN supplementation per day over the course of 4 weeks. Diabetes-associated inflammatory biomarkers and relevant biochemical and physical parameters were tested pre-and post-intervention, and participants' dietary inflammatory potential was estimated.

resultsA significant reduction in the pro-inflammatory biomarkers' interleukin-6, interleukin-18, and tumour necrosis factor-α was observed in the T2D group. In addition, some, but not all, biochemical parameters including fasting blood glucose, low-density lipoprotein cholesterol and uric acid were significantly improved in T2D-at-risk group. Moreover, a significant difference was detected between the DII scores of the healthy and T2D groups. DII score for the T2D group was consistent with an anti-inflammatory diet.

conclusionAnti-inflammatory potential of dietary ACN in T2D participants was evidenced in the present study. Although, anti-inflammatory dietary patterns of T2D participants may have accelerated the anti-inflammatory effect of the ACN capsules supplemented in this trial.

Indexed as

Dietary SupplementsAdultAgedAnthocyaninsAnti-Inflammatory AgentsBiomarkersBlood GlucoseCholesterol, LDLCytokinesDiabetes Mellitus, Type 2HumansInflammationLeptinMiddle AgedUric AcidAnthocyaninsAnti-Inflammatory AgentsBiomarkersBlood GlucoseCholesterol, LDLCytokinesLeptinUric AcidAnthocyaninDietary inflammatory indexDietary patternPro-inflammatory biomarkersType 2 diabetes

Identifiers

PMID33576837
OpenAlexW3128219601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.