ArticlePlant physiology2021
Fanconi anemia ortholog FANCM regulates meiotic crossover distribution in plants.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Monitoring the stability of transgene expression in lettuce using the RUBY reporter.Plant cell reports · 2025Article
- RECQ4 restricts non-interfering crossover formation to fine-tune meiotic recombination rates in rice.Plant biotechnology journal · 2025Article
- MutL homolog 1 participates in interference-sensitive meiotic crossover formation in soybean.Plant physiology · 2024Article
- Plant reproduction research in Latin America: Toward sustainable agriculture in a changing environment.Plant-environment interactions (Hoboken, N.J.) · 2024Review
- HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- MSH2 stimulates interfering and inhibits non-interfering crossovers in response to genetic polymorphism.Nature communications · 2023Article
- Repair of DNA double-strand breaks in plant meiosis: role of eukaryotic RecA recombinases and their modulators.Plant reproduction · 2023Review
- Characterization and acceleration of genome shuffling and ploidy reduction in synthetic allopolyploids by genome sequencing and editing.Nucleic acids research · 2023Article
- FANCM promotes class I interfering crossovers and suppresses class II non-interfering crossovers in wheat meiosis.Nature communications · 2022Article
- Review
- Regulation of interference-sensitive crossover distribution ensures crossover assurance inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Structural Maintenance of Chromosomes 5/6 Complex Is Necessary for Tetraploid Genome Stability inFrontiers in plant science · 2021Article
- The Formation of Bivalents and the Control of Plant Meiotic Recombination.Frontiers in plant science · 2021Review
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meiotic recombination increases genetic diversity and manipulation of its frequency and distribution holds great promise in crop breeding. In Arabidopsis thaliana, FANCM (a homolog of mammalian Fanconi anemia complementation group M) suppresses recombination and its function seems conserved in other species including the rosids Brassica spp. and pea (Pisum sativum), and the monocot rice (Oryza sativa). To examine the role of FANCM during meiotic recombination in lettuce (Lactuca sativa, an asterid), we characterized the function of lettuce LsFANCM and found that it can functionally substitute for AtFANCM in transgenic Arabidopsis plants. Moreover, three independent CRISPR/Cas9-edited lettuce Lsfancm mutants showed reduced pollen viability and seed setting. Unexpectedly, analyses of chromosome behavior revealed that 77.8% of Lsfancm meiocytes exhibited univalents. The normal formation of double-strand breaks in DNA and the discontinuous assembly of synaptonemal complex in Lsfancm mutants supports the hypothesis that LsFANCM might be dispensable for the initiation of meiotic recombination but required for normal synapsis. Furthermore, the frequency of lettuce HEI10 (Human Enhancer of Invasion 10) foci, a marker for Class-I crossovers (COs), was similar between wild-type (WT) and Lsfancm. Strikingly, the distribution of LsHEI10 foci and chiasmata in Lsfancm meiotic chromosomes was markedly different from the WT. A similar alteration in the distribution of Class-I COs was also observed in the Arabidopsis Atfancm mutant. Taken together, these results demonstrate that FANCM is important for shaping the distribution of meiotic Class-I COs in plants, and reveal an evolutionarily divergent role for FANCM in meiotic bivalent formation between Arabidopsis and lettuce.
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