Evidence map›Paper›PMID 33576776›Full record

ReviewThe Journal of infectious diseases2021

Protection and Risk: Male and Female Genital Microbiota and Sexually Transmitted Infections.

Susan Tuddenham, Jacques Ravel, Jeanne M Marrazzo

Abstract readReview
In one paragraph

Review in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. The Vaginal Microbiome: Setting the Stage for Cancer?The Journal of infectious diseases · 2025
    Article
  9. Article
  10. Vaginally-delivered fast-dissolving antibody tablets (FDAT) for on-demand non-hormonal contraception and multi-purpose protection.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  11. Review
  12. All Properties of Infertility Microbiome in a Review Article.Journal of clinical laboratory analysis · 2025
    Review
  13. Microbes Saving Lives and Reducing Suffering.Microbial biotechnology · 2025
    Article
  14. Observational
  15. Comparison of the urinary microbiome in men who have sex with men with and without Chlamydia trachomatis infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  16. Review
  17. Understanding the influence of the microbiome on childhood infections.Expert review of anti-infective therapy · 2024
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Susan TuddenhamDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Jacques RavelInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-0851-2233
Jeanne M MarrazzoDepartment of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.

Funding

Elucidating causes of vaginal symptoms using a multi-omics approach - Admin. SupplementR01NR015495 · NINR · UNIVERSITY OF MARYLAND BALTIMORE · PI FORNEY, LARRY J, RAVEL, JACQUES · 2016 to 2020
$2.6M
Dysbiosis, Recurrent Bacterial Vaginosis and the Vaginal MicrobiomeK23AI125715 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TUDDENHAM, SUSAN ANNE · 2016 to 2020
$972k
NIAID NIH HHS K23 AI125715NINR NIH HHS R01 NR015495
6 · The paper itself

Abstract

Unique compositional and functional features of the cervicovaginal microbiota have been associated with protection against and risk for sexually transmitted infections (STI). In men, our knowledge of the interaction between the penile microbiota and STI is less developed. The current state of our understanding of these microbiota and their role in select STIs is briefly reviewed, along with strategies that leverage existing findings to manipulate genital microbiota and optimize protection against STIs. Finally, we focus on major research gaps and present a framework for future studies.

Indexed as

MicrobiotaFemaleGenitalia, FemaleGenitalia, MaleHumansMaleSexually Transmitted DiseasesanaerobesLactobacillusmicrobiomepenileSTIvagina

Identifiers

PMID33576776
PMCPMC8206802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.