Evidence map›Paper›PMID 33576637›Full record

ArticleNano letters2021

Imaging of Cell Morphology Changes via Metamaterial-Assisted Photobleaching Microscopy.

Yeon Ui Lee, Clara Posner, Junxiang Zhao, Jin Zhang, Zhaowei Liu

Abstract read
In one paragraph

Article in Nano letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Hyperbolic polariton-coupled emission optical microscopy.Nanophotonics (Berlin, Germany) · 2025
    Article
  2. Metamaterial-Assisted Illumination Nanoscopy with Exceptional Axial Resolution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  3. Article
  4. Article
  5. Microscopies Enabled by Photonic Metamaterials.Sensors (Basel, Switzerland) · 2022
    Review
  6. Organic Hyperbolic Material Assisted Illumination Nanoscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yeon Ui LeeDepartment of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID 0000-0001-8857-1251
Clara PosnerDepartment of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Junxiang ZhaoDepartment of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Jin ZhangDepartment of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID 0000-0001-7145-7823
Zhaowei LiuDepartment of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID 0000-0002-5732-8109

Funding

Live-cell Activity Architecture in CancerR35CA197622 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jin Zhang · 2015 to 2026
$11.2M
MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008326 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 1989 to 2020
$7.5M
NCI NIH HHS R35 CA197622NIGMS NIH HHS T32 GM008326
6 · The paper itself

Abstract

Determining the axial position of an emitter with nanoscale precision is critical to a fundamental imaging methodology. While there are many advanced optical techniques being applied to high-resolution imaging, high-axial-resolution topography imaging of living cells is particularly challenging. Here, we present an application of metamaterial-assisted photobleaching microscopy (MAPM) with high-axial resolution to characterize morphological properties of living cells. Quantitative imaging of changes in the morphology of live cells is obtained by topographic and statistical analysis. The time-lapse topography image using the metamaterial-induced photostability provides information about growth factor induced changes in the cell morphology with high-axial resolution.

Indexed as

PhotobleachingMicroscopy, FluorescenceHyperbolic metamaterialsMetamaterialsMorphology changesPhotobleachingSuperaxial-resolution microscopyTopographic imaging

Identifiers

PMID33576637
PMCPMC8858031

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.