ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2021
Aging-related shift of eccrine sweat glands toward the skin surface due to tangling and rotation of the secretory ducts revealed by digital 3D skin reconstruction.
Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
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- Human Skin Aging: Physiology and Pathophysiology.Biology · 2026Article
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- Eccrine Coil Elastosis: A New Dermatopathological Feature Associated With Prediabetes and Diabetes.Journal of cutaneous pathology · 2025Article
- Cold temperatures, hot risks: perioperative hypothermia in geriatric patients - a narrative review.Anesthesia and pain medicine · 2025Review
- Decoding Precision Aging: The Intersection of Cognitive Decline, Frailty, and Hormonal Biomarkers.Gerontology · 2025Article
- Research progress on the role of fascia in skin wound healing.Burns & trauma · 2025Review
- A comparative study of passive drug diffusion through human skin via intercellular and sweat duct route: effect of aging.Drug delivery and translational research · 2024Article
- Article
- Juvenile-onset Skin Fragility with Acral Blistering: A Quiz.Acta dermato-venereologica · 2024Article
- Effects of skin moisturization on various aspects of touch showing differences with age and skin site.Scientific reports · 2023Article
- Fat infiltration into dermal layer induces aged facial appearance by decreasing dermal elasticity.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022Article
- Quantitative characterization of 3D structure of vellus hair arrector pili muscles by micro CT.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022Article
- Infiltration of subcutaneous adipose layer into the dermal layer with aging.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022Article
- Aging-related shift of eccrine sweat glands toward the skin surface due to tangling and rotation of the secretory ducts revealed by digital 3D skin reconstruction.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2021Article
- Impact of Noncommunicable Diseases and Heat Stress on Estimated Glomerular Filtration Rate in Security Officers at a Tertiary Care Hospital in South India.Indian journal of nephrologyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSweat gland function deteriorates with aging, leading to loss of heat tolerance. However, it is unclear whether and how the structure of sweat glands changes during aging, because the 3D structure is complex and inaccessible.
methodsTo clarify age-dependent changes in sweat glands, we developed a method for 3D structure analysis of sweat glands by means of X-ray micro-CT observation of human skin specimens followed by 3D digital reconstruction on computer (digital 3D skin).
resultsComparison of eccrine sweat glands of abdominal skin from young and old subjects showed that the density and volume of sweat glands do not change with aging. In contrast, the depth of the secretory coil from the skin surface is decreased in the aged group. Surprisingly, the secretory ducts appear tortuous or meandering though their length is unchanged. The secretory coils are located at the dermal-adipose layer boundary in both groups, but the thickness of the dermal layer decreases with aging, and the depth of the coils is correlated with the dermal thickness.
conclusionOur results suggest that sweat glands twist and rotate with aging to maintain the position of the coil at the dermal-adipose boundary, causing an overall shift toward the skin surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.