Evidence map›Paper›PMID 33576535›Full record

ArticleMagnetic resonance in medicine2021

Deuterated water imaging of the rat brain following metabolism of [

Rohit Mahar, Huadong Zeng, Anthony Giacalone, Mukundan Ragavan, Thomas H Mareci, Matthew E Merritt

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Magnetic Resonance Applications to Metabolism.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  8. NMR-Based Stable Isotope Tracing of Cancer Metabolism.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. [6,6'-NMR in biomedicine · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. What to feed or what not to feed-that is still the question.Metabolomics : Official journal of the Metabolomic Society · 2021
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rohit MaharDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-9801-4173
Huadong ZengAdvanced Magnetic Resonance Imaging and Spectroscopy Facility, College of Medicine, University of Florida, Gainesville, Florida, USA.
Anthony GiacaloneDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Mukundan RagavanDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-8678-4229
Thomas H MareciDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Matthew E MerrittDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-4617-9651
University of Florida · US

Funding

TR&D3-SCHP41GM122698 · NIGMS · FLORIDA STATE UNIVERSITY · PI BREY, WILLIAM W, CROSS, TIMOTHY A · 2017 to 2021
$6.7M
Web Portal CoreU2CDK119889 · NIDDK · UNIVERSITY OF FLORIDA · PI YOST, RICHARD A. · 2018 to 2021
$1.9M
Imaging Hepatic Gluconeogenesis with Hyperpolarized DihydroxyacetoneR01DK105346 · NIDDK · UNIVERSITY OF FLORIDA · PI MERRITT, MATTHEW E · 2016 to 2020
$1.7M
Upgrade of an 11T/40cm MRI/S SystemS10RR025671 · NCRR · UNIVERSITY OF FLORIDA · PI EDISON, ARTHUR S · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025671NIDDK NIH HHS R01 DK105346NIDDK NIH HHS U2C DK119889NIGMS NIH HHS P41 GM122698
6 · The paper itself

Abstract

purposeTo determine whether deuterated water (HDO) generated from the metabolism of [

methodsA bolus of [

resultsThe background HDO signal could be detected and imaged before glucose injection. The

conclusionMetabolic imaging of HDO, as a marker of glucose, lactate, and glutamate/glutamine metabolism, has been shown here for the first time. Cerebral glucose metabolism can be assessed efficiently using a standard gradient-echo sequence that provides superior in-plane resolution compared with CSI-based techniques.

Indexed as

GlucoseWaterAnimalsBrainCarbon IsotopesGlutamic AcidGlutamineRatsRats, Sprague-DawleyCarbon IsotopesGlucoseGlutamic AcidGlutamineWater[2H7]glucosebrainDMRIHDOmetabolism

Identifiers

PMID33576535
PMCPMC7953892
OpenAlexW3129074784

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.