Evidence map›Paper›PMID 33576448›Full record

ArticleInternational journal of molecular medicine2021

CircUSP36 knockdown alleviates oxidized low‑density lipoprotein‑induced cell injury and inflammatory responses in human umbilical vein endothelial cells via the miR‑20a‑5p/ROCK2 axis.

Jun Miao, Bo Wang, Ran Shao, Yan Wang

Open access · hybridAbstract read
In one paragraph

Article in International journal of molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jun Miao *Department of Cardiology, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277100, P.R. China.
Bo Wang *Department of Cardiology, Zaozhuang Hospital of Zaozhuang Mining Group, Zaozhuang, Shandong 277100, P.R. China.
Ran ShaoNursing Department, Zaozhuang Hospital of Traditional Chinese Medicine, Zaozhuang, Shandong 277100, P.R. China.
Yan WangNursing Department, Zaozhuang Hospital of Traditional Chinese Medicine, Zaozhuang, Shandong 277100, P.R. China.
Zaozhuang Municipal Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dysfunctions of human umbilical vein endothelial cells (HUVECs) are important features of atherosclerosis (AS). Circular RNAs (circRNAs) are regulators of a wide range of human diseases, including AS. The present study aimed to investigate the role of circUSP36 in the ectopic phenotype of HUVECs and to provide evidence of the involvement of circUSP36 in the pathogenesis of AS. AS cell models

Indexed as

ApoptosisAtherosclerosisBlotting, WesternCell CycleCell MovementCell SurvivalComputational BiologyEnzyme-Linked Immunosorbent AssayHumansHuman Umbilical Vein Endothelial CellsImmunoprecipitationLipoproteins, LDLOxidative Stressrho-Associated KinasesUbiquitin ThiolesteraseLipoproteins, LDLoxidized low density lipoproteinrho-Associated KinasesROCK2 protein, humanUbiquitin ThiolesteraseUSP36 protein, humanatherosclerosiscircUSP36human umbilical vein endothelial cellmiR‑20a‑5pROCK2

Identifiers

PMID33576448
PMCPMC7891832
OpenAlexW3126195042

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.