Evidence map›Paper›PMID 33576167›Full record

SynthesisCancer medicine2021

Role of surgery in treating epstein-barr virus-associated smooth muscle tumor (EBV-SMT) with central nervous system invasion: A systemic review from 1997 to 2019.

Ka-Wei Lau, Yu-Wei Hsu, Yin-Ting Lin, Ko-Ting Chen

Abstract readSystematic Review
In one paragraph

Synthesis in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Epstein-Barr Virus-Associated Smooth-Muscle Tumor of the Brain.AJNR. American journal of neuroradiology · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. [Epstein-Barr virus-associated smooth muscle tumor in a girl].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ka-Wei LauCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Yu-Wei HsuCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Yin-Ting LinCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Ko-Ting ChenDepartment of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.ORCID 0000-0002-6795-5974

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) is a rare mesenchymal tumor occurred almost exclusively in immunocompromised hosts. This article provides a systematic review of literature under PRISMA guideline on clinical features, treatment modalities, roles of surgical intervention, and outcomes of all 65 reported EBV-SMTs with central nervous system (CNS) invasion. Over 95% of reported cases were immunocompromised, while human immunodeficiency virus infection and post-organ transplantation were the most commonly associated underlying causes (near 90%). Despite a heterogeneous follow-up period, a 1-year survival rate of 76.0% and 5-year survival rate of 59.6% may support the indolent and non-deadly nature of EBV-SMT even with CNS invasion. Immune survey and reconstruction should be conducted for every patient with CNS EBV-SMT. Surgical resection is mostly adopted as primary treatment to obtain diagnosis and relieve compressive effect. A total resection of tumor may be beneficial if tumor was symptomatic and had intracranial invasion.

Indexed as

Herpesvirus 4, HumanAdultCentral Nervous System NeoplasmsEpstein-Barr Virus InfectionsFemaleHIV InfectionsHumansImmunocompromised HostMaleNeoplasm InvasivenessOrgan TransplantationPostoperative ComplicationsSmooth Muscle TumorSurvival RateTreatment OutcomeCNS invasionEBV-SMTimmune compromisedsurgical resection

Identifiers

PMID33576167
PMCPMC7940242

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.