Evidence map›Paper›PMID 33576105›Full record

ArticleHuman brain mapping2021

The variability of MR axon radii estimates in the human white matter.

Jelle Veraart, Erika P Raven, Luke J Edwards, Nikolaus Weiskopf, Derek K Jones

Abstract read
In one paragraph

Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jelle VeraartBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0003-0781-0420
Erika P RavenBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.
Luke J EdwardsDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Nikolaus WeiskopfDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Derek K JonesCUBRIC, School of Psychology, Cardiff University, Cardiff, UK.

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Christopher M Collins · 2014 to 2026
$19.3M
Mesoscopic Biomarkers of Neurodegeneration with Diffusion MRIR01NS088040 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FIEREMANS, ELS, NOVIKOV, DMITRY S · 2014 to 2023
$5.2M
Resolving Fine Architectures of Human Gray Matter with Ultra-High-Resolution Diffusion MRIR01EB025133 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GE, YULIN, ZHANG, JIANGYANG · 2017 to 2018
$1.3M
Longitudinal Characterization of Postnatal Brain Maturation after Fetal Zika InfectionF32HD103313 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RAVEN, ERIKA PRATT · 2020 to 2022
$180k
NIBIB NIH HHS P41 EB017183NIBIB NIH HHS R01 EB025133NICHD NIH HHS F32 HD103313NINDS NIH HHS R01 NS088040Wellcome TrustWellcome Trust 096646/Z/11/ZWellcome Trust 104943/Z/14/Z
6 · The paper itself

Abstract

The noninvasive quantification of axonal morphology is an exciting avenue for gaining understanding of the function and structure of the central nervous system. Accurate non-invasive mapping of micron-sized axon radii using commonly applied neuroimaging techniques, that is, diffusion-weighted MRI, has been bolstered by recent hardware developments, specifically MR gradient design. Here the whole brain characterization of the effective MR axon radius is presented and the inter- and intra-scanner test-retest repeatability and reproducibility are evaluated to promote the further development of the effective MR axon radius as a neuroimaging biomarker. A coefficient-of-variability of approximately 10% in the voxelwise estimation of the effective MR radius is observed in the test-retest analysis, but it is shown that the performance can be improved fourfold using a customized along-tract analysis.

Indexed as

AxonsAdultBrainDiffusion Magnetic Resonance ImagingHumansNeuroimagingReproducibility of ResultsWhite Matteraxon diameterdiffusion MRIreproducibilityvariability

Identifiers

PMID33576105
PMCPMC8046139

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.