Evidence map›Paper›PMID 33575918›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2021

Use of the Long-Term Conditions Questionnaire (LTCQ) for monitoring health-related quality of life in people affected by cognitive impairment including dementia: pilot study in UK memory clinic services.

Caroline M Potter, Michele Peters, Maureen Cundell, Rupert McShane, Ray Fitzpatrick

Open access · hybridAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. What Are the Important Health and Well-Being Outcome Dimensions for Parent Carers of Disabled Children? A Qualitative Study.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
  2. Article
  3. Article
  4. Living well while providing support: validation of LTCQ-Carer for assessing informal carers' quality of life.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Caroline M PotterNuffield Department of Population Health, Health Services Research Unit, University of Oxford, Oxford, UK. caroline.potter@dph.ox.ac.uk.ORCID http://orcid.org/0000-0001-7128-968X
Michele PetersNuffield Department of Population Health, Health Services Research Unit, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-0076-5981
Maureen CundellOxford Health NHS Foundation Trust, Oxford, UK.
Rupert McShaneOxford Health NHS Foundation Trust, Oxford, UK.
Ray FitzpatrickNuffield Department of Population Health, Health Services Research Unit, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0003-0607-0563
Oxford Health NHS Foundation Trust · GBUniversity of Oxford · GB

Funding

National Institute of Health Research (GB) Collaboration for Leadership in Applied Health Research and Care - Oxford
6 · The paper itself

Abstract

purposeThe aim of this study was to validate the Long-Term Conditions Questionnaire (LTCQ) among patients using memory clinic services in England. LTCQ is a short self-administered measure of 'living well with long-term conditions' that has not been previously tested in patients with cognitive impairment.

methodsThe mixed-methods study included cognitive interviews to test the comprehensibility and content validity of LTCQ from the patient's perspective, followed by a pilot survey to test the measure's internal consistency, construct validity, structural validity, and responsiveness. Participants were recruited through memory clinics following a diagnosis of mild cognitive impairment or dementia.

resultsInterview respondents (n = 12) all found LTCQ's content relevant, with only minor formatting modifications required. Among survey respondents (n = 105), most patients (86%) were able to self-report answers to LTCQ. High multimorbidity among the sample was associated with reduced LTCQ and EQ-5D scores. Internal consistency of LTCQ was high (Cronbach's α = 0.93), no floor or ceiling effects were observed, and missing data levels were low. Factor analysis results further supported LTCQ's structural validity, and predicted positive correlation with EQ-5D indicated construct validity. Score changes observed in a four-month follow-up survey (n = 61) are suggestive of LTCQ's responsiveness.

conclusionLTCQ is a valid means of assessing health-related quality of life for people living with cognitive impairment (including dementia) in the early period of support following diagnosis. Owing to high levels of multimorbidity in this patient population, LTCQ offers an advantage over dementia-specific measures in capturing the cumulative impact of all LTCs experienced by the patient.

Indexed as

Health StatusCognitive DysfunctionDementiaEnglandHumansMaleMemoryMiddle AgedMultimorbidityPilot ProjectsPsychometricsQuality of LifeReproducibility of ResultsSelf ReportSurveys and QuestionnairesUnited KingdomCognitive impairmentDementiaHealth-related quality of lifeLong-Term Conditions QuestionnaireMultimorbidityPatient-reported outcome measure

Identifiers

PMID33575918
PMCPMC8178132
OpenAlexW3119422732

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.