Evidence map›Paper›PMID 33575903›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2021

Perioperative Blood Management of Preoperative Anemia Determines Long-Term Outcome in Patients with Pancreatic Surgery.

F Oehme, S Hempel, R Knote, D Addai, M Distler, B Muessle, U Bork, J Weitz, T Welsch, C Kahlert

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Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

F OehmeDepartment for Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany.ORCID 0000-0003-4997-8176
S HempelDepartment for Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany.
R KnoteDepartment for Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany.
D AddaiDepartment for Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany.
M DistlerDepartment for Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany.
B MuessleDepartment for Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany.
U BorkDepartment for Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany.
J WeitzDepartment for Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany.
T WelschDepartment for Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany.
C KahlertDepartment for Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany. christoph.kahlert@uniklinikum-dresden.de.
University Hospital Carl Gustav Carus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background/purposeAnemia affects the postoperative course of patients undergoing a major surgical procedure. However, it remains unclear whether anemia has a different impact on the long-term outcome of patients with malignant or benign pancreatic disease.

methodsA retrospective analysis of patients undergoing pancreatic surgery for pancreatic malignancies or chronic pancreatitis was conducted between January 2012 and June 2018 at the University Hospital Dresden, Germany. The occurrence of preoperative anemia and the administration of pre-, intra-, and postoperative blood transfusions were correlated with postoperative complications and survival data by uni- and multivariate analysis.

resultsA total of 682 patients were included with 482 (70.7%) undergoing surgical procedures for pancreatic malignancies. Univariate regression analysis confirmed preoperative anemia as a risk factor for postoperative complications > grade 2 according to the Clavien-Dindo classification. Multivariate regression analyses indicated postoperative blood transfusion as an independent risk factor for postoperative complications in patients with a benign (OR 20.5; p value < 0.001) and a malignant pancreatic lesion (OR 4.7; p value < 0.01). Univariate and multivariate analysis revealed preoperative anemia and pre-, intra-, and postoperative blood transfusions as independent prognostic factors for shorter overall survival in benign and malignant patients (p value < 0.001-0.01).

conclusionPreoperative anemia is a prevalent, independent, and adjustable factor in pancreatic surgery, which poses a significant risk for postoperative complications irrespective of the entity of the underlying disease. It should therefore be understood as an adjustable factor rather than an indicator of underlying disease severity.

Indexed as

AnemiaDigestive System Surgical ProceduresBlood TransfusionHumansPostoperative ComplicationsRetrospective StudiesRisk FactorsAnemiaLong-term survivalPancreatic diseasePancreatic surgeryTransfusion

Identifiers

PMID33575903
OpenAlexW3129057768

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.