ArticleBiotechnology letters2021
Continuous production of fructooligosaccharides by recycling of the thermal-stable β-fructofuranosidase produced by Aspergillus niger.
Article in Biotechnology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 17 citations in OpenAlex.
- Effective synthesis of high-content fructooligosaccharides in engineered Aspergillus niger.Microbial cell factories · 2024Article
- Recent developments in the production of prebiotic fructooligosaccharides using fungal fructosyltransferases.Mycology · 2024Review
- Energy- and evolution-based design of inulosucrase for enhanced thermostability and inulin production.Applied microbiology and biotechnology · 2023Article
- A novel sucrose-inducible expression system and its application for production of biomass-degrading enzymes in Aspergillus niger.Biotechnology for biofuels and bioproducts · 2023Article
- Oligosaccharides production from coprophilous fungi: An emerging functional food with potential health-promoting properties.Biotechnology reports (Amsterdam, Netherlands) · 2022Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo achieve continuous production of fructooligosaccharides (FOS) by recycling of the mycelial cells containing the thermal-stable β-fructofuranosidase in Aspergillus niger without immobilization.
resultsThe thermal-stable β-fructofuranosidase FopA-V1 was successfully expressed in A. niger ATCC 20611 under the control of the constitutive promoter PgpdA. The engineered A. niger strain FV1-11 produced the β-fructofuranosidase with improved thermostability, which remained 91.2% of initial activity at 50 °C for 30 h. Then its mycelial β-fructofuranosidase was recycled for the synthesis of FOS. It was found that the enzyme still had 79.3% of initial activity after being reused for six consecutive cycles, whereas only 62.3% β-fructofuranosidase activity was detected in the parental strain ATCC 20611. Meanwhile, the FOS yield of FV1-11 after six consecutive cycles reached 57.1% (w/w), but only 51.0% FOS yield was detected in ATCC 20611.
conclusionsThe thermal-stable β-fructofuranosidase produced by A. niger can be recycled to achieve continuous synthesis of FOS with high efficiency, providing a powerful and economical strategy for the industrial production of FOS.
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