ArticleMolecular genetics and genomics : MGG2021
Genome-wide transcriptome and translatome analyses reveal the role of protein extension and domestication in liver cancer oncogenesis.
Article in Molecular genetics and genomics : MGG, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 21 citations in OpenAlex.
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- Translation stalling induced mitochondrial entrapment of ribosomal quality control related proteins offers cancer cell vulnerability.Research square · 2024Article
- Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations.Journal of applied genetics · 2024Article
- Hepatitis B virus (HBV) codon adapts well to the gene expression profile of liver cancer: an evolutionary explanation for HBV's oncogenic role.Journal of microbiology (Seoul, Korea) · 2022Article
- SARS-CoV-2 competes with host mRNAs for efficient translation by maintaining the mutations favorable for translation initiation.Journal of applied genetics · 2022Article
- Translational regulation by ribosome-associated quality control in neurodegenerative disease, cancer, and viral infection.Frontiers in cell and developmental biology · 2022Review
- Mutation profiling of a limbless pig reveals genome-wide regulation of RNA processing related to bone development.Journal of applied genetics · 2021Article
- Comparative genomic analysis of a naturally born serpentized pig reveals putative mutations related to limb and bone development.BMC genomics · 2021Article
- Genome-wide expression changes mediated by A-to-I RNA editing correlate with hepatic oncogenesis.Translational cancer research · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
One gene could be transcribed to different RNA isoforms, and then produce various forms of protein sequences. This mechanism largely diversifies the cellular pool and allows natural selection to select from a wider range of substrates. In the cancer field, the isoform switches between tumor and normal tissues, such as the alternative splicing, stop codon read-through, or protein domestication, are significantly ignored by the traditional differential expression analyses. The intention of this work is to fill this gap. We collected public transcriptome and translatome data from ten patients with liver cancer, and performed genome-wide comparison on the stop codon read-through and protein domestication events. Both events diversify the proteome during long-term evolution. Surprisingly, we found that the tumor tissues globally have higher occurrence of stop codon read-through events as well as protein domestication events (translation signals of non-coding repetitive elements). These read-through and domestication events show limited overlapping across the ten patients, indicating the randomness of their occurrence and their deleterious nature. These tumor-specific events might have been purged by natural selection if they are not collected timely. Our work manifests the role of protein extension and domestication in liver cancer oncogenesis, adding new aspects to the cancer field.
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