ArticleNeurosurgery2021
Electrocorticography During Deep Brain Stimulation Surgery: Safety Experience From 4 Centers Within the National Institute of Neurological Disorders and Stroke Research Opportunities in Human Consortium.
Article in Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Stimulation-evoked orbitofrontal activity as a biomarker for DBS personalization in depression.medRxiv : the preprint server for health sciences · 2026Article
- Electrocorticography During Deep Brain Stimulation Surgery for Movement Disorders: Single-Center Experience.Brain sciences · 2026Article
- Substantia nigra pars reticulata involvement in auditory hallucinations of treatment-resistant schizophrenia: a deep brain stimulation case report.Schizophrenia (Heidelberg, Germany) · 2026Article
- Scalp block improves electrophysiological stability and patient cooperation during deep brain stimulation surgery.Scientific reports · 2025Article
- Lexicality-Modulated Influence of Auditory Cortex on Subthalamic Nucleus During Motor Planning for Speech.Neurobiology of language (Cambridge, Mass.) · 2023Article
- Article
- Translational Organic Neural Interface Devices at Single Neuron Resolution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Finely-tuned gamma oscillations: Spectral characteristics and links to dyskinesia.Experimental neurology · 2022Review
- Differentiation of speech-induced artifacts from physiological high gamma activity in intracranial recordings.NeuroImage · 2022Article
- Articulatory Gain Predicts Motor Cortex and Subthalamic Nucleus Activity During Speech.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, interventional psychiatry, and women in neuromodulation.Frontiers in human neuroscience · 2022Article
- Clinical neurophysiology of Parkinson's disease and parkinsonism.Clinical neurophysiology practice · 2022Review
- How Human Single-Neuron Recordings Can Help Us Understand Cognition: Insights from Memory Studies.Brain sciences · 2021Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundIntraoperative research during deep brain stimulation (DBS) surgery has enabled major advances in understanding movement disorders pathophysiology and potential mechanisms for therapeutic benefit. In particular, over the last decade, recording electrocorticography (ECoG) from the cortical surface, simultaneously with subcortical recordings, has become an important research tool for assessing basal ganglia-thalamocortical circuit physiology.
objectiveTo provide confirmation of the safety of performing ECoG during DBS surgery, using data from centers involved in 2 BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative-funded basic human neuroscience projects.
methodsData were collected separately at 4 centers. The primary endpoint was complication rate, defined as any intraoperative event, infection, or postoperative magnetic resonance imaging abnormality requiring clinical follow-up. Complication rates for explanatory variables were compared using point biserial correlations and Fisher exact tests.
resultsA total of 367 DBS surgeries involving ECoG were reviewed. No cortical hemorrhages were observed. Seven complications occurred: 4 intraparenchymal hemorrhages and 3 infections (complication rate of 1.91%; CI = 0.77%-3.89%). The placement of 2 separate ECoG research electrodes through a single burr hole (84 cases) did not result in a significantly different rate of complications, compared to placement of a single electrode (3.6% vs 1.5%; P = .4). Research data were obtained successfully in 350 surgeries (95.4%).
conclusionCombined with the single report previously available, which described no ECoG-related complications in a single-center cohort of 200 cases, these findings suggest that research ECOG during DBS surgery did not significantly alter complication rates.
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Registered trials
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